Results 91 to 100 of about 64,409 (290)

Extracellular vesicles: mechanisms and prospects in type 2 diabetes and its complications

Frontiers in Endocrinology
Extracellular vesicles (EVs) are small vesicles released by cells into the surrounding environment, carrying biomolecules such as proteins, miRNA, etc., involved in intercellular communication and regulation of biological processes.
Zijian Liu, Ruiyang Yin, Jiaxing Tian, Jiaxing Tian   +3 more
doaj   +1 more source

Rapid Nickel-based Isolation of Extracellular Vesicles from Different Biological Fluids

Bio-Protocol, 2020
Extracellular vesicles (EVs) are membranous structures that cells massively release in extracellular fluids. EVs are cargo of cellular components such as lipids, proteins, and nucleic acids that can work as a formidable source in liquid biopsy studies ...
Michela Notarangelo, Deborah Ferrara, Cristina Potrich, Lorenzo Lunelli, Lia Vanzetti, Alessandro Provenzani, Manuela Basso, Alessandro Quattrone, Vito D'Agostino   +8 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

Cell Reports, 2018
Summary: The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct ...
Scott A. Hinger, Diana J. Cha, Jeffrey L. Franklin, James N. Higginbotham, Yongchao Dou, Jie Ping, Lihua Shu, Nripesh Prasad, Shawn Levy, Bing Zhang, Qi Liu, Alissa M. Weaver, Robert J. Coffey, James G. Patton   +13 more
doaj   +1 more source

Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

Pharmaceutics, 2020
Extracellular vesicles (EVs) are small membrane-based nanovesicles naturally released from cells. Extracellular vesicles mimetics (EVMs) are artificial vesicles engineered from cells or in combination with lipid materials, and they mimic certain ...
Prakash Gangadaran, Byeong-Cheol Ahn
doaj   +1 more source

The definition of exosome and extracellular vesicles (EV)

, 2019
Membrane trafficking by exosomes has been the subject of intense investigation due to their diagnostic and therapeutic potential. However, although exosomes have been referred to by most authors as extracellular vesicles of endosomal origin, there are no extracellular vesicle-specific markers that can distinguish exosomes from other vesicle types ...
openaire   +1 more source

An Extracellular Vesicle (EV) Paper Strip for Rapid and Convenient Estimation of EV Concentration

Biosensors
Extracellular vesicles (EVs) have emerged as promising biomarkers and therapeutic agents, yet their quantification remains technically challenging due to the limitations of conventional methods. Here, a low-cost, fluorescence-based, paper-strip immunoassay is presented for rapid and semi-quantitative estimation of EV concentration, inspired by pH ...
Gisela Ströhle, Rebecca Goodrum, Huiyan Li   +2 more
openaire   +3 more sources

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

, 2019
Mutations in β-catenin, especially at the residues critical for its degradation, render it constitutively active. Here, we show that mutant β-catenin can be transported via extracellular vesicles (EVs) and activate Wnt signalling pathway in the recipient
Liem, M, Fonseka, P, Samuel, M,, Gangoda, L, Keerthikumar, S, Collins, C, Kalra, H, Boukouris, S, Al, Saffar H, Chitti, SV   +9 more
core   +1 more source

Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles

Pharmacological Research
Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication.
Siyu Hao, Hongyu Yang, Jiaojiao Hu, Lili Luo, Yuan Yuan, Libing Liu   +5 more
doaj   +1 more source