Results 41 to 50 of about 64,409 (290)

A Single Extracellular Vesicle (EV) Flow Cytometry Approach to Reveal EV Heterogeneity [PDF]

Angewandte Chemie International Edition, 2018
AbstractExtracellular vesicles (EVs) actively participate in intercellular communication and pathological processes. Studying the molecular signatures of EVs is key to reveal their biological functions and clinical values, which, however, is greatly hindered by their sub‐100 nm dimensions, the low quantities of biomolecules each EV carries, and the ...
Wen Shen, Kaizhu Guo, Gary Brent Adkins, Qiaoshi Jiang, Yang Liu, Sabrina Sedano, Yaokai Duan, Wei Yan, Shizhen Emily Wang, Kristina Bergersen, Danielle Worth, Emma H. Wilson, Wenwan Zhong   +12 more
openaire   +5 more sources

Engineered EVs for Oxidative Stress Protection

Pharmaceuticals, 2021
Extracellular vesicles (EVs) are increasingly studied as vectors for drug delivery because they can transfer a variety of molecules across biological barriers. SerpinB3 is a serine protease inhibitor that has shown a protective anti-apoptotic function in
Anna Maria Tolomeo, Santina Quarta, Alessandra Biasiolo, Mariagrazia Ruvoletto, Michela Pozzobon, Giada De Lazzari, Ricardo Malvicini, Cristian Turato, Giorgio Arrigoni, Patrizia Pontisso, Maurizio Muraca   +10 more
doaj   +1 more source

Single‐vesicle imaging and co‐localization analysis for tetraspanin profiling of individual extracellular vesicles

, 2021
Extracellular vesicles (EVs) are secreted nano-sized vesicles that contain cellular proteins, lipids, and nucleic acids. Although EVs are expected to be biologically diverse, current analyses cannot adequately characterize this diversity because most are
Kang, H., Yongmin Kwon, Jingeol Lee, Johan Yi, Kang, M., Jaehun Jung, Lee, H., Lee, J., Yi, J., Chungmin Han, Minsu Kang, Jung, J., Park, J., Jaesung Park, Hyejin Kang, Han, C., Hyunjin Lee, Kwon, Y.   +17 more
core   +1 more source

Extracellular Vesicle (EV) Array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping

Journal of Extracellular Vesicles, 2013
BackgroundExosomes are one of the several types of cell‐derived vesicles with a diameter of 30–100 nm. These extracellular vesicles are recognized as potential markers of human diseases such as cancer. However, their use in diagnostic tests requires an objective and high‐throughput method to define their phenotype and determine their concentration in ...
Jørgensen, Malene ; id_orcid 0000-0003-1381-3863, Bæk, Rikke, Pedersen, Shona; id_orcid 0000-0001-6636-0293, Søndergaard, Evo Kristina Lindersson, Kristensen, Søren R; id_orcid 0000-0002-2649-506X, Varming, Kim   +5 more
openaire   +4 more sources

Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication [PDF]

Biomedicines, 2020
Pancreatic cancer is malignant and the seventh leading cause of cancer-related deaths worldwide. However, chemotherapy and radiotherapy are—at most—moderately effective, indicating the need for new and different kinds of therapies to manage this disease.
Sokviseth Moeng, Seung Wan Son, Jong Sun Lee, Han Yeoung Lee, Tae Hee Kim, Soo Young Choi, Hyo Jeong Kuh, Jong Kook Park   +7 more
openaire   +3 more sources

Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages [PDF]

, 2022
Macrophages are important antigen presenting cells which can release extracellular vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be broadly classified into M1 ‘classical’ and M2 ‘alternatively‐activated’ macrophages.
Clements, Toby, Abrahams, Vikki M, Pantazi, Paschalia, Morten Venø, Veno, Morten, Paschalia Pantazi, Toby Clements, Beth Holder, Holder, Beth, Vikki M. Abrahams, Abrahams, Vikki M., Venø, Morten   +11 more
core   +1 more source

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors [PDF]

Journal of Extracellular Vesicles, 2019
ABSTRACTIt is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell‐to‐cell communication, both in physiological and pathological conditions. Once outside the cell, these vesicles are termed extracellular vesicles (EVs).
Mariadelva Catalano, Lorraine O'Driscoll
openaire   +5 more sources

EV duty vehicles: Features and functions of ciliary extracellular vesicles

Frontiers in Genetics, 2022
The primary cilium is a microtubule-based organelle that extends from a basal body at the surface of most cells. This antenna is an efficient sensor of the cell micro-environment and is instrumental to the proper development and homeostatic control of organs.
Ludovic Vinay, Clémence Belleannée
openaire   +3 more sources

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis [PDF]

International Journal of Molecular Sciences, 2020
Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells. EVs are recognized as powerful means of intercellular communication since they contain many signaling molecules (including lipids, proteins, and nucleic acids). In parallel, changes in epigenetic processes can lead to changes in gene function and finally lead
Muraca M., Cappariello A.
openaire   +2 more sources

Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis

Frontiers in Immunology, 2019
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk ...
Bartijn C. H. Pieters, Alfredo Cappariello, Martijn H. J. van den Bosch, Peter L. E. M. van Lent, Anna Teti, Fons A. J. van de Loo   +5 more
doaj   +1 more source