Results 91 to 100 of about 140,375 (300)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Research Progress on the Functions and Applications of Prunus domestica L. Processing Wastes and Their Active Components [PDF]

open access: yesShipin Kexue
Prunus domestica L., a member of the genus Prunus of the family Rosaceae, is known as a “third-generation functional fruit” due to its high nutritional value.
HE Pan, LU Min, YAN Jie, WEI Die, XI Meng, GU Xin
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Innovative methods of extracting the loose gold from technogenic deposits in the Irkutsk region

open access: yesMATEC Web of Conferences, 2018
In Russia and abroad, the scope of the use of gold has significantly expanded, which undoubtedly affected the level of production. However, despite the fairly high rates of gold mining, the economic situation that has developed in recent years makes the ...
Golovina Elena   +2 more
doaj   +1 more source

Comparative Study on the Extraction and Quantification of Polyphenols from Citrus Peels Using Maceration and Ultrasonic Technique

open access: yesCurrent Research in Nutrition and Food Science Journal, 2019
Citrus processing industry generates the large amount of byproducts, which are rich in polyphenols that have high antioxidant properties. These polyphenols can be extracted and utilized in different applications.
Anuradha Saini, P. Panesar, M. B. Bera
semanticscholar   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Leveraging LLMs for legal terms extraction with limited annotated data

open access: yesArtificial Intelligence and Law
The legal industry is characterized by the presence of dense and complex documents, which necessitate automatic processing methods to manage and analyse large volumes of data.
Julien Breton   +6 more
semanticscholar   +1 more source

Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions

open access: yesChemistry Central Journal, 2017
Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts.
M. Molnar   +4 more
semanticscholar   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Research progress on the extraction process of natural components from Zanthoxylum bungeanum and its application in food

open access: yesShipin yu jixie
Zanthoxylum bungeanum is native to China and is a traditional food seasoning and traditional Chinese medicine. It plays an important role in food processing and disease prevention. In this article, the research progress of Z.
QU Yanfeng   +4 more
doaj   +1 more source

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