Results 51 to 60 of about 109,918 (262)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Eco-Friendly Recovery of Biocompounds from Agro-Industrial By-Products Using Non-Thermal Processing

Clean Technologies
The valorization of agro-industrial by-products through sustainable extraction of bio-compounds is a key challenge within circular economy and clean-processing frameworks, as large volumes of tomato and artichoke residues are generated by the food ...
Maria N. Berradre, Cristina Arroqui, Idoya Fernández-Pan, María José Beriain, Francisco C. Ibañez, Paloma Vírseda   +5 more
doaj   +1 more source

An analysis of the Extractive Industry Transparency Initiative implementation process

World Development, 2018
Abstract The Extractive Industries Transparency Initiative (EITI) has become an international hallmark of the efforts to promote better extractive-sector management and improved societal development in natural resource-rich countries. Since its establishment in 2003, a large number of resource-dependent countries have committed to the EITI Standard ...
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Integrating AI with medical industry chain data: enhancing clinical nutrition research through semantic knowledge graphs

Frontiers in Digital Health
In clinical nutrition research, the medical industry chain generates a wealth of multidimensional spatial data across various formats, including text, images, and semi-structured tables.
Deng Chen, ChengJie Lu, HongPeng Bai, Kaijian Xia, Meilian Zheng   +4 more
doaj   +1 more source

Forecast of brine blowout zones in the Amu Darya basin and analysis of brine blowout in oil and gas fields [PDF]

Glasnik Srpskog Geografskog Društva
The purpose of this study is to forecast possible brine blowout zones in the Amu Darya basin and further analyse these manifestations in oil and gas fields to assess their potential for hydrocarbon extraction.
Deryaev Annaguly
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Ultrasound assisted extraction of bioactive compounds

Croatian Journal of Food Science and Technology, 2010
Many novel and innovative techniques are nowadays researched and explored in order to replace or improve classical, thermal processing technologies.
Helena Drmić, Anet Režek Jambrak
doaj