Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
PlantsLeaves of Gentiana lutea L., traditionally used for treating heart disorders, represent a sustainable and underutilized source of bitter secoiridoids and xanthones, also found in Gentianae radix—an official herbal drug derived from the same, protected ...
Katarina Šavikin +6 more
doaj +1 more source
Quantifying Fracture Dynamics in Clean Energy: A Novel Fractal Perspective [PDF]
E3S Web of ConferencesGeothermal energy, as an emergent source of power, has consistently been a focal point of scholarly investigation both domestically and internationally, with a particular emphasis on the prediction and assessment of its extraction efficiency.
Ye Dayu, Liu Guannan, Feng Gao
doaj +1 more source
Optimizing the process of supercritical extraction of lemon balm (Melissa Officinalis L.) [PDF]
, 2010 This work investigates the process of extraction of lemon balm (Melissa officinalis L.) by treatment with carbon dioxide at supercritical conditions. The process kinetics is studied at different operational conditions, and the influence of some important
Angelov, George +3 more
core +1 more source
Ultrasound increases the aqueous extraction of phenolic compounds with high antioxidant activity from olive pomace [PDF]
, 2018 Olive pomace is a waste produced by the olive oil industry in massive quantities each year. Disposal of olive pomace is difficult due to high concentrations of phenolic compounds, which is an environmental concern.
Goldsmith, Chloe D. +4 more
core +2 more sources
Optimization of extraction parameters on the antioxidant properties of banana waste.
Acta scientiarum polonorum. Technologia alimentaria, 2016 BACKGROUND Banana is grown worldwide and consumed as ripe fruit or used for culinary purposes. Peels form about 18-33% of the whole fruit and are discarded as a waste product.
Pui Yee Toh +4 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Extraction of crystal-field parameters for lanthanide ions from quantum-chemical calculations
, 2010 A simple method for constructing effective Hamiltonians for the 4fN and 4fN-15d energy levels of lanthanide ions in crystals from quantum-chemical calculations is presented.
Duan, C. K. +4 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Extraction of alignment parameters from circular dichroic photoelectron angular distribution (CDAD) measurements [PDF]
, 1986 In a previous paper, we showed that circular dichroism in photoelectron angular distributions (CDAD) can be used to probe alignment in gas phase atoms and linear molecules. Often this alignment is parametrized through the moments of alignment A(2), A(4),
Dixit, S. N. +2 more
core +1 more source