Results 61 to 70 of about 17,427 (222)

Dermatologic Features of Endocrine Tumor Syndromes—Systematic Review and Meta‐Analysis

International Journal of Dermatology, Volume 65, Issue 3, Page 464-488, March 2026.
ABSTRACT Endocrine tumor syndromes, including multiple endocrine neoplasia types 1, 2A, and 2B (MEN1, MEN2A, MEN2B), Carney complex (CNC), and PTEN hamartoma tumor syndrome (PHTS), are hereditary conditions characterized by multisystem tumor development.
Sára Pálla, Zseraldin Metyovinyi, Fanni Adél Meznerics, Arash Mirzahosseini, Judit Tőke, Miklós Tóth, Henriett Butz, Attila Patócs, Márta Medvecz   +8 more
wiley   +1 more source

Imaging features of an extramammary Paget’s disease of the penis: A case report and literature review

Radiology Case Reports
Extramammary Paget’s disease is a rare cutaneous malignant neoplasm, and few studies have described its radiological features. Herein, we report the case of an 83-year-old man with extramammary Paget’s disease and condyloma acuminatum.
Mana Shimomura, MD, Kenta Ikushima, MD, Takayoshi Shinya, MD, PhD, Yoichi Otomi, MD, PhD, Yoshiro Abe, MD, PhD, Hisanori Uehara, MD, PhD, Junya Furukawa, MD, PhD, Yoshiaki Kubo, MD, PhD, Ichiro Hashimoto, MD, PhD, Masafumi Harada, MD, PhD   +9 more
doaj   +1 more source

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease

Cell Research, 2020
Mammary and extramammary Paget’s Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown.
Yongli Song, C. Guerrero-Juarez, Zhongjian Chen, Yichen Tang, Xianghui Ma, Cong Lv, Xueyun Bi, Min Deng, Lina Bu, Yuhua Tian, Ruiqi Liu, Ran Zhao, Jiuzhi Xu, Xiaole Sheng, Sujuan Du, Yeqiang Liu, Yunlu Zhu, Shi-jun Shan, Hong-Duo Chen, Yiqiang Zhao, Guangbiao Zhou, Jianwei Shuai, F. Ren, L. Xue, Zhaoxia Ying, X. Dai, C. Lengner, B. Andersen, M. Plikus, Q. Nie, Zhengquan Yu   +30 more
semanticscholar   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Neoadjuvant use of Imiquimod Before Surgery in Extramammary Paget’s Disease [PDF]

, 2018
A doença de Paget extramamária (DPEM) é uma neoplasia maligna cutânea, rara, observada principalmente em mulheres caucasianas pós-menopausa. A cirurgia é o tratamento mais comum.
Azevedo, F., Costa e Silva, M., Costa, J. S., Costa, M. A., Lisboa, Carmen   +4 more
core   +2 more sources

Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds.
Yaoyao Kong, Haixia Wang, Nan Cao, Pengcheng Huai, Zhenzhen Wang, Chaoqi Zuo, Xueqing Wang, Yilei Wu, Yongxia Liu, Shengli Chen, Hong Liu, Guangliang Zhang   +11 more
wiley   +1 more source

Anal gland adenocarcinoma in situ with pagetoid spread: a case report

Surgical Case Reports, 2018
Background Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. Case presentation Physical examination
Kohei Ishioka, Fumikazu Koyama, Hiroyuki Kuge, Takashi Inoue, Shinsaku Obara, Takayuki Nakamoto, Yoshiyuki Sasaki, Yasuyuki Nakamura, Maiko Takeda, Chiho Ohbayashi, Masamitsu Kuwahara, Masayuki Sho   +11 more
doaj   +1 more source

HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses

Cancers, 2022
Simple Summary The prognosis for advanced Extramammary Paget’s disease (EMPD) is almost always poor. HER2-targeted antibody–drug conjugates (ADCs) such as trastuzumab emtansine and trastuzumab deruxtecan have proven to be effective against HER2-positive ...
K. Tokuchi, T. Maeda, S. Kitamura, T. Yanagi, H. Ujiie   +4 more
semanticscholar   +1 more source

First Case of Primary Breast Melanoma in Central America: Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Primary breast melanoma is an exceedingly rare neoplasm, accounting for < 0.5% of all malignant breast tumors. Its scarcity and highly variable clinical presentation often delay diagnosis and complicate management. We report the case of a 55‐year‐old woman with a primary non‐cutaneous melanoma of the right breast initially misdiagnosed as high‐
Ana García‐Urbina, Denis Espinoza‐Vásquez, Johanna Obregón‐Silva, Arlin Montoya Rodríguez   +3 more
wiley   +1 more source

Prostate carcinoma metastatic to the skin as an extrammamary Paget’s disease

Diagnostic Pathology, 2012
Aim The current paper describes a case of prostatic adenocarcinoma metastatic to the skin presenting as an extrammamary Paget's disease, a very rare and poorly characterised morphological entity. We report a case of prostatic carcinoma metastatic to skin
Petcu Eugen, Gonzalez-Serva Aldo, Wright Robert G, Slevin Mark, Brinzaniuc Klara   +4 more
doaj   +1 more source