Results 61 to 70 of about 5,282,350 (229)

HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses

Cancers, 2022
Simple Summary The prognosis for advanced Extramammary Paget’s disease (EMPD) is almost always poor. HER2-targeted antibody–drug conjugates (ADCs) such as trastuzumab emtansine and trastuzumab deruxtecan have proven to be effective against HER2-positive ...
K. Tokuchi, T. Maeda, S. Kitamura, T. Yanagi, H. Ujiie   +4 more
semanticscholar   +1 more source

Two cases reports of extramammary Paget's disease with adenocarcinoma [PDF]

, 1994
Two patients who suffered from extramammary Paget's disease with adenocarcinoma were treated with combination chemotherapy. Both patients who complained of scrotal induration were the Paget's cells with undifferentiated adenocarcinoma in pathology.
近藤, 猪一郎, 志村, 英俊, 村井, 哲夫, 三浦, 猛   +3 more
core  

Large Anogenital Bowen Disease Misdiagnosed as Chronic Eczema for Nine Years: A Case Report Highlighting the Importance of Early Biopsy

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Persistent treatment‐resistant anogenital plaques should not be repeatedly managed as chronic eczema without histopathological confirmation. Early biopsy of atypical or non‐resolving lesions facilitates timely diagnosis of Bowen disease, prevents prolonged diagnostic delay, and enables treatment before progression to invasive squamous cell ...
Shiwani Sharma Acharya, Sanket Bishokarma, Uma Giri   +2 more
wiley   +1 more source

Anal gland adenocarcinoma in situ with pagetoid spread: a case report

Surgical Case Reports, 2018
Background Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. Case presentation Physical examination
Kohei Ishioka, Fumikazu Koyama, Hiroyuki Kuge, Takashi Inoue, Shinsaku Obara, Takayuki Nakamoto, Yoshiyuki Sasaki, Yasuyuki Nakamura, Maiko Takeda, Chiho Ohbayashi, Masamitsu Kuwahara, Masayuki Sho   +11 more
doaj   +1 more source

Prevalence of extramammary Paget’s disease in urban China: a population-based study

Orphanet Journal of Rare Diseases, 2020
Background Extramammary Paget’s disease (EMPD) is an intraepithelial adenocarcinoma. The chronic relapsing clinical course and unbearable clinical symptoms of extramammary Paget’s disease usually result in a markedly diminished quality of life.
Shilu Yin, Lu Xu, Sheng-Feng Wang, Jingnan Feng, Li-Li Liu, Guo-Zhen Liu, Jin-Xi Wang, S. Zhan, Z. Zhao, P. Gao   +9 more
semanticscholar   +1 more source

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum

Precision Radiation Oncology, Volume 10, Issue 2, Page 120-126, June 2026.
An elderly male patient with extramammary Paget disease of the scrotum and multiple metastases was treated with fractionated FLASH‐RT (40 Gy in 5 fractions) in the scrotal lesion. Abstract Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
wiley   +1 more source

Extramammary Paget’s Disease of the Scrotal and Penile: A Case Report and Review of the Literature

Urologia internationalis
Introduction: Extramammary Paget’s disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, and clinical and pathological characteristics are not very clear.
Xun-Guo Yang, Han Lin, Zhen-Hua Gao, Xing-Qi Wang, Ling Li, Dao-Ming Tian, Yu-Bin Wen, Ji-Hong Shen   +7 more
semanticscholar   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Invasive Vulval Paget’s disease treated with primary radiotherapy: A rare case report and literature review

Gynecologic Oncology Reports, 2020
Extramammary Vulval Paget’s Disease (VPD) is rare neoplasm of post-menopausal women. In relatively young perimenopausal patients, it can cause both diagnostic dilemma and therapeutic challenges. Majority of VPD is of non-invasive variety.
Avir Sarkar, S.C. Saha, Pooja Sikka, Neha Kumari, Pranab Dey, Bhavana Rai   +5 more
doaj   +1 more source

A PILOT STUDY OF TOPICAL IMIQUIMOD THERAPY FOR THE TREATMENT OF RECURRENT EXTRAMAMMARY PAGET'S DISEASE

Gynecologic Oncology, 2016
Objective The objective of this prospective pilot study was to assess the clinical and histologic effects of topical imiquimod therapy on recurrent extramammary Paget's disease of the vulva.
R. Cowan, D. Black, Ho-Ang Lien, Kay J. Park, R. Soslow, F. Backes, G. Gardner, Nadeen R. Abu-Rustum, M. Leitao, E. Eisenhauer, D. Chi   +10 more
semanticscholar   +1 more source