Results 61 to 70 of about 4,843,090 (191)

Scrotal squamous cell carcinoma: Two HPV‐negative cases with probable UV‐ induced pathogenesis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Daniel Craus, Ulrike Wieland, Steffi Silling, Julia Hyun, Milan Vidakovic, Frank Oellig, Alexander Kreuter, Valentina Laura Müller   +7 more
wiley   +1 more source

Consensus on Human Epidermal Growth Factor Receptor 2 Overexpression Testing in Pan‐Tumor

Cancer Innovation, Volume 5, Issue 2, April 2026.
This is the first pan‐tumor human epidermal growth factor receptor 2 (HER2) testing consensus established by a national expert panel in China, addressing critical gaps in HER2 overexpression testing across solid tumors beyond breast and gastric cancers.
Zhe Wang, Lin Chen, Wei Rao, Baoshan Cao, Muyan Cai, Xiangshan Fan, Yuan Ji, Yuan Li, Yan Song, Yan Sun, Yu Sun, Chunyan Wu, Qingxin Xia, Yanfeng Xi, Liyan Xue, Rutie Yin, Han Liang, Jianming Ying   +17 more
wiley   +1 more source

Management of Extramammary Paget's Disease: A Case Report and Review of the Literature [PDF]

, 2013
Extramammary Paget's Disease (EMPD) is a rare condition of the skin that often involves the vulva, perianal region, scrotum, penis, and axilla. Although prognosis is generally favorable, it can be associated with neoplasms of the bladder, urethra ...
Rosa Guerra, Subhasis Misra
core   +1 more source

Vulvar Adenocarcinoma With Pagetoid Spread: A Case Report

Cancer Reports
Background In rare cases, cancer cells adjacent to the skin migrate intraepithelially and reach the epidermis, presenting a histological appearance similar to that of Paget's disease; this phenomenon is termed pagetoid spread. Herein, we report a case of
Kazuaki Nishimura, Seiji Kagami, Haruka Kajio, Tamaki Wada, Naoyuki Toki, Kiyoshi Yoshino   +5 more
doaj   +1 more source

Perianal Paget's Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Perianal Paget's disease is rare and may be secondary to an underlying anorectal adenocarcinoma. Full‐thickness biopsy with immunohistochemistry is key to distinguish primary from secondary disease and to guide staging. Wide local excision is standard, while radiotherapy is a reasonable option when radical surgery is declined.
Daniela Lira, Maria Reigota Miranda, Marta Serra, Margarida Martins, Júlio Alves, Joana Noronha   +5 more
wiley   +1 more source

Extramammary Paget’s disease of the scrotum

Journal of the Chinese Medical Association, 2011
Extramammary Paget's disease is an uncommon intra-epidermal malignant neoplasm that arises in area rich in apocrine glands. Common sites of occurrence include the vulva, perianal region, perineum, and scrotum. The lesion may be accompanied by an invasive adenocarcinoma or adenocarcinoma in situ of the apocrine glands.
Juang, Guang-Dar, Lin, Meng-Yan, Hwang, Thomas I-Sheng   +2 more
openaire   +2 more sources

Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease [PDF]

, 2010
While mammary Paget's disease (MPD) is clearly linked to breast cancer, the histogenesis of extramammary Paget's disease (EMPD) is controversial. Recently NY-BR-1, a differentiation antigen expressed in the breast and in skin adnexal structures was ...
Giger, O, Moch, H, Varga, Z, Alix O'Meara, Alexander Knuth, Caduff, R, O'Meara, A, Rosmarie Caduff, Dirk Jäger, Olivier Giger, Pierre-Andre Diener, Knuth, A, Diener, P A, Jäger, D, Zsuzsanna Varga, Holger Moch   +15 more
core   +1 more source

Perianal Paget’s Disease in a Forty-Five-Year-Old Man and Review of the Literature [PDF]

Iranian Journal of Colorectal Research, 2015
Introduction Extramammary Paget’s disease is a rare neoplasm of the skin that might develop in perianal region. Although different management options are available, wide local excision is still the method of choice.
Yavar Shams Hojjati, Abbas Abdollahi, Ghodratollah Maddah, Asieh Sadat Fattahi   +3 more
doaj   +1 more source

Dermatologic Features of Endocrine Tumor Syndromes—Systematic Review and Meta‐Analysis

International Journal of Dermatology, Volume 65, Issue 3, Page 464-488, March 2026.
ABSTRACT Endocrine tumor syndromes, including multiple endocrine neoplasia types 1, 2A, and 2B (MEN1, MEN2A, MEN2B), Carney complex (CNC), and PTEN hamartoma tumor syndrome (PHTS), are hereditary conditions characterized by multisystem tumor development.
Sára Pálla, Zseraldin Metyovinyi, Fanni Adél Meznerics, Arash Mirzahosseini, Judit Tőke, Miklós Tóth, Henriett Butz, Attila Patócs, Márta Medvecz   +8 more
wiley   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source