Results 101 to 110 of about 3,418,189 (307)
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
The extremal solution of a boundary reaction problem [PDF]
, 2015 We consider Delta u = 0 in Omega, partial derivative u/partial derivative v = lambda f(u) on Gamma(1), u= 0 on Gamma(2) where lambda > 0, f(u) = e(u) or f(u) = (1 + u)(p), Gamma(1), Gamma(2) is a partition of partial derivative Omega and Omega subset of ...
Dupaigne, L, Montenegro, M, Davila, J
core
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Instability of black holes in AdS3 × S3
Nuclear Physics BExtremal and near extremal black holes are unstable, unless they are protected by supersymmetry. For black holes in AdS3 × S3, we study the range of parameters that bound the unstable region, the fate of extremal black holes that are unstable, and the ...
Finn Larsen, Siyul Lee
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Extreme value theory for moving average processes with light-tailed innovations [PDF]
, 2005 We consider stationary infinite moving average processes of the form $Y_n = \sum c_i Z_{n+i}$, where the sum ranges over the integers, (Z_i) is a sequence of iid random variables with ``light tails'' and (c_i) is a sequence of positive and summable ...
Lindner, Alexander M. +2 more
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Extremal Events in a Bank Operational Losses [PDF]
Operational losses are true dangers for banks since their maximal values to signal default are difficult to predict. This risky situation is unlike default risk whose maximum values are limited by the amount of credit granted.
Daniel Zajdenweber +2 more
core
Properties of enhançons in supergravity [PDF]
, 2003 A certain class of naked singularities, related to N = 2 pure super Yang-Mills theory, are resolved in string theory with the enhançon mechanism. We study the properties of the enhançon in supergravity.
Dimitriadis, Apostolos A.
core
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source