Results 71 to 80 of about 449,317 (315)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Vulnerability of floodways under extreme flood events
, 2015 Floodways are commonly used in rural road networks due to the economic and environmental benefits offered as a low-cost and practical road crossing in flood-prone areas.
Lokuge, Weena +3 more
core +1 more source
WINTER EXTREME EVENTS – ROMANIAN CARPATHIAN AVALANCHES [PDF]
Aerul şi Apa: Componente ale Mediului, 2017 The study presents a statistics of avalanche cases recorded in Romanian Carpathians over the years, most of them since February 2004, when the National Meteorological Administration program for snow and avalanches started, but also from Mountain Rescue ...
A. PAŞOL, C. GRECU, U. RECKERTH
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
PULSAR OBSERVATIONS OF EXTREME SCATTERING EVENTS [PDF]
The Astrophysical Journal, 2015 Extreme scattering events (ESEs) in the interstellar medium (ISM) were first observed in regular flux measurements of compact extragalactic sources. They are characterized by a flux variation over a period of weeks, suggesting the passage of a 'diverging plasma lens' across the line of sight (LOS).
W. A. Coles +19 more
openaire +7 more sources
Extreme weather events inWest Hungary
International Journal of Horticultural Science, 2010 Agricultural production is a rather risky activity, as it is largely exposed to extreme weather events. This paper focuses on the frost and hail data in springtime, affecting fruit production in West Hungary.
Z. Mézes +5 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Scaling in the timing of extreme events [PDF]
Chaos, Solitons & Fractals, 2015 Extreme events can come either from point processes, when the size or energy of the events is above a certain threshold, or from time series, when the intensity of a signal surpasses a threshold value. We are particularly concerned by the time between these extreme events, called respectively waiting time and quiet time.
openaire +4 more sources
Social SciencesStudies in public policy have suggested that disasters can potentially serve as “focusing events”, catalyzing significant changes to disaster risk reduction (DRR) policies and practices. How and why this effect does (or does not) ensue, and for how long,
Barry S. Levitt, Richard S. Olson
doaj +1 more source
Extreme heat events heighten soil respiration
Scientific Reports, 2021 In the wake of climate change, extreme events such as heatwaves are considered to be key players in the terrestrial biosphere. In the past decades, the frequency and severity of heatwaves have risen substantially, and they are projected to continue to ...
Hassan Anjileli +6 more
doaj +1 more source