Results 71 to 80 of about 1,990,424 (342)

Coherence and predictability of extreme events in irregular waves [PDF]

, 2012
This paper concerns the description and the predictability of a freak event when at a certain position information in the form of a time signal is given.
Groesen, E. van, Latifah, A.L.
core   +5 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Midwinter Dry Spells Amplify Post‐Fire Snowpack Decline

Geophysical Research Letters, 2023
Increasing wildfire and declining snowpacks in mountain regions threaten water availability. We combine satellite‐based fire detections with snow seasonality classifications to examine fire activity in California's seasonal and ephemeral snow zones.
Benjamin J. Hatchett, Arielle L. Koshkin, Kristen Guirguis, Karl Rittger, Anne W. Nolin, Anne Heggli, Alan M. Rhoades, Amy E. East, Erica R. Siirila‐Woodburn, W. Tyler Brandt, Alexander Gershunov, Kayden Haleakala   +11 more
doaj   +1 more source

Extreme events in excitable systems and mechanisms of their generation

, 2013
We study deterministic systems, composed of excitable units of FitzHugh-Nagumo type, that are capable of self-generating and self-terminating strong deviations from their regular dynamics without the influence of noise or parameter change.
Ansmann, Gerrit, Feudel, Ulrike, Karnatak, Rajat, Lehnertz, Klaus   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Prediction of extreme events in the OFC model on a small world network

, 2010
We investigate the predictability of extreme events in a dissipative Olami-Feder-Christensen model on a small world topology. Due to the mechanism of self-organized criticality, it is impossible to predict the magnitude of the next event knowing previous
A. Corral, A. Corral, A. Garber, A. Garber, A. Helmstetter, D. Marsan, D.J. Watts, E. Casarotti, F. Caruso, F. Caruso, F. Caruso, H. Kantz, J. Neyman, L. Crescentini, M.S. Mega, M.S. Mega, P. Bak, P. Bak, P. Tosi, P.A. Varotsos, S. Abe, S. Lise, T. Parsons, X. Yang, Y.Y. Kagan, Z. Olami   +25 more
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Riddled Basins of Attraction in Systems Exhibiting Extreme Events [PDF]

, 2017
Using a system of two FitzHugh-Nagumo units, we demonstrate the occurrence of riddled basins of attraction in delay-coupled systems as the coupling between the units is increased.
Feudel, Ulrike, Saha, Arindam
core   +2 more sources