Results 81 to 90 of about 1,990,424 (342)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Public Support for Disaster Risk Reduction: Evidence from The Bahamas Before and After Hurricane Dorian

open access: yesSocial Sciences
Studies in public policy have suggested that disasters can potentially serve as “focusing events”, catalyzing significant changes to disaster risk reduction (DRR) policies and practices. How and why this effect does (or does not) ensue, and for how long,
Barry S. Levitt, Richard S. Olson
doaj   +1 more source

Extreme weather events inWest Hungary

open access: yesInternational Journal of Horticultural Science, 2010
Agricultural production is a rather risky activity, as it is largely exposed to extreme weather events. This paper focuses on the frost and hail data in springtime, affecting fruit production in West Hungary.
Z. Mézes   +5 more
doaj   +1 more source

WINTER EXTREME EVENTS – ROMANIAN CARPATHIAN AVALANCHES [PDF]

open access: yesAerul şi Apa: Componente ale Mediului, 2017
The study presents a statistics of avalanche cases recorded in Romanian Carpathians over the years, most of them since February 2004, when the National Meteorological Administration program for snow and avalanches started, but also from Mountain Rescue ...
A. PAŞOL, C. GRECU, U. RECKERTH
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz   +3 more
wiley   +1 more source

Urbanization in megacities increases the frequency of extreme precipitation events far more than their intensity

open access: yesEnvironmental Research Letters, 2020
More than half of the world’s population lives in urban areas (UN Population Division 2018 The World’s cities in 2018 (UN: New York)), which are especially vulnerable to climate extremes (Field et al 2012 Managing the Risks of Extreme Events and ...
Louis Marelle   +5 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli   +5 more
wiley   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce   +72 more
wiley   +1 more source

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