Results 31 to 40 of about 111,108 (251)
Journal of Low Power Electronics and Applications, 2021 This work presents a dynamically reconfigurable architecture for Neural Network (NN) accelerators implemented in Field-Programmable Gate Array (FPGA) that can be applied in a variety of application scenarios.
Hasan Irmak +4 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A High Throughput FPGA-Based Implementation of the Lanczos Method for the Symmetric Extremal Eigenvalue Problem [PDF]
, 2012 Iterative numerical algorithms with high memory bandwidth requirements but medium-size data sets (matrix size ˜ a few 100s) are highly appropriate for FPGA acceleration. This paper presents a streaming architecture comprising floating-point operators coupled with high-bandwidth on-chip memories for the Lanczos method, an iterative algorithm for ...
Abid Rafique +2 more
openaire +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Single-Tray VLM vs Dual-Tray VLM: Quantitative Throughput Comparison
Tehnički Glasnik, 2021 In this paper quantitative comparison of resulting throughputs for single-tray and dual-tray VLM devices is presented. Comparison is based on mathematical models for throughput approximating dual command times of VLM’s crane, for selected parameters of ...
Goran Đukić +3 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Scientific Reports, 2021 A mechanical time-of-flight filter intended for measurement of velocities of nanoparticles exiting a gas aggregation source has been developed. Several configurations maximizing simplicity, throughput or resolution are suggested and investigated both ...
Pavel Solař +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source