Results 51 to 60 of about 111,108 (251)

BICEP/Keck. XIX. Extremely Thin Composite Polymer Vacuum Windows for BICEP and Other High-throughput Millimeter-wave Telescopes

The Astrophysical Journal
Millimeter-wave refracting telescopes targeting the degree-scale structure of the cosmic microwave background (CMB) have recently grown to diffraction-limited apertures of over 0.5 m.
P. A. R. Ade, Z. Ahmed, M. Amiri, D. Barkats, R. Basu Thakur, C. A. Bischoff, D. Beck, J. J. Bock, H. Boenish, V. Buza, K. Carter, J. R. Cheshire IV, J. Connors, J. Cornelison, L. Corrigan, M. Crumrine, S. Crystian, A. J. Cukierman, E. Denison, L. Duband, M. Echter, M. Eiben, B. D. Elwood, S. Fatigoni, J. P. Filippini, A. Fortes, M. Gao, C. Giannakopoulos, N. Goeckner-Wald, D. C. Goldfinger, J. A. Grayson, A. Greathouse, P. K. Grimes, G. Hall, G. Halal, M. Halpern, E. Hand, S. A. Harrison, S. Henderson, J. Hubmayr, H. Hui, K. D. Irwin, J. H. Kang, K. S. Karkare, S. Kefeli, J. M. Kovac, C. Kuo, K. Lau, M. Lautzenhiser, A. Lennox, T. Liu, K. G. Megerian, M. Miller, L. Minutolo, L. Moncelsi, Y. Nakato, H. T. Nguyen, R. O’Brient, S. Paine, A. Patel, M. A. Petroff, A. R. Polish, T. Prouve, C. Pryke, C. D. Reintsema, T. Romand, D. Santalucia, A. Schillaci, B. Schmitt, E. Sheffield, B. Singari, K. Sjoberg, A. Soliman, T. St Germaine, A. Steiger, B. Steinbach, R. Sudiwala, K. L. Thompson, C. Tsai, C. Tucker, A. D. Turner, C. Vergès, A. G. Vieregg, A. Wandui, A. C. Weber, J. Willmert, W. L. K. Wu, H. Yang, C. Yu, L. Zeng, C. Zhang, S. Zhang, (BICEP/Keck Collaboration)   +92 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Analysis on the difference of bacterial flora structure and gene function of medium-high-temperature Daqu in Hetao and Yingtan area [PDF]

Zhongguo niangzao
Bacterial flora structure of medium-high-temperature Daqu in the Hetao area of Bayannur, Inner Mongolia was analyzed by high-throughput sequencing technology, the comparative analysis of Alpha and Beta diversity was conducted with the bacterial flora of ...
ZHANG Qing, HOU Qiangchuan, LI Qing, ZHANG Min, REN Guojun, WANG Yao, GUO Zhuang
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Beware of N-Benzoyloxybenzamides

Molecules
Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, 1.
Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E. Gardiner, Benson M. Kariuki, Simon E. Ward, Emyr Lloyd-Evans, Helen Waller-Evans, D. Heulyn Jones   +9 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A hybrid neural architecture: Online attosecond x-ray characterization [PDF]

APL Machine Learning
The emergence of high-repetition-rate x-ray free-electron lasers (XFELs), such as SLAC’s LCLS-II, serves as our canonical example for autonomous controls that necessitate high-throughput diagnostics paired with streaming computational pipelines capable ...
J. Hirschman, B. Mencer, A. Shackelford, R. Obaid, R. Coffee   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source