Results 31 to 40 of about 29,130 (214)

Twin pregnancies and the limits of the energetics of gestation and growth hypothesis

The Anatomical Record, EarlyView.
Abstract The “Energetics of Gestation and Growth” (EGG) hypothesis proposes that human birth timing and the associated secondary altriciality of human newborns is determined by limits in maternal metabolic capacity. According to this model, labor is triggered when the increasing fetal energy requirements exceed the expectant mother's maximum sustained ...
Cédric Cordey, Nicole M. Webb, Martin Haeusler   +2 more
wiley   +1 more source

Treatment of patent ductus arteriosus and short-term outcomes among extremely preterm infants: a multicentre cohort studyResearch in context

EClinicalMedicine
Summary: Background: The optimal treatment strategy for patent ductus arteriosus (PDA) in extremely preterm infants is currently highly controversial.
Aimin Qian, Siyuan Jiang, Xinyue Gu, Shujuan Li, Xiaoping Lei, Wei Shi, Jianguo Zhou, Liyuan Hu, Tiantian Xiao, Yanping Zhu, Yun Cao, Lizhong Du, Wenhao Zhou, Shoo K. Lee, Rui Cheng, Rong Yin   +15 more
doaj   +1 more source

The mechanism of labor in nonhuman primates: A look inside

The Anatomical Record, EarlyView.
Abstract While in humans, the flexed position of the fetus and its rotating course down the birth canal are well documented, in other primates the mechanism of labor is unknown. Despite the lack of comparative data, it is commonly assumed that the human obstetric mechanism is unique, and anthropologists have disputed when and why the transition to the ...
Melissa K. Stoller
wiley   +1 more source

A biomimetic ducted nipple reveals gestational age‐dependent deficits in suction generation in a neonatal pig model

The Anatomical Record, EarlyView.
Abstract All infant mammals must suckle in order to effectively acquire milk from a nipple. Yet, not all infants are able to do so. Preterm infants in particular face significant feeding challenges, often failing to establish successful breastfeeding due to complex neurophysiologic challenges.
Max Sarmet, Emily C. Volpe, Elska B. Kaczmarek, Maressa E. Kennedy, Ani E. Smith, Hannah E. Shideler, Harlow I. Smith, Dylan J. Anderson, Thomas H. Stroud, Christopher J. Mayerl   +9 more
wiley   +1 more source

Immune profiles and growth outcomes in very and extremely preterm infants with bronchopulmonary dysplasia: A prospective cohort study

Pediatrics and Neonatology
Background: Preterm birth is associated with immune dysregulation, and bronchopulmonary dysplasia (BPD) is the most prevalent complication affecting preterm infants.
Mei-Hsuan Ho, Shen-Hao Lai, Ming-Chou Chiang, Reyin Lien, Kai-Hsiang Hsu, Ren-Huei Fu, Shih-Ming Chu, En-Pei Lee, Chih-Yung Chiu   +8 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

A comprehensive analysis of clinical variables for severe bronchopulmonary dysplasia in extremely preterm infants

Pediatrics and Neonatology
Background: Identifying clinical risk factors that may forecast the development of severe bronchopulmonary dysplasia (BPD) in very and extremely premature infants can assist clinicians in implementing early interventions to reduce long-term morbidity and
Yi-Ling Tung, Shih-Ming Chu, Reyin Lien, Ren-Huei Fu, Kai-Hsiang Hsu, Ming-Chou Chiang, Chih-Yung Chiu   +6 more
doaj   +1 more source

A Review on Non-invasive Respiratory Support for Management of Respiratory Distress in Extremely Preterm Infants

Frontiers in Pediatrics, 2020
Majority of extremely preterm infants require positive pressure ventilatory support at the time of delivery or during the transitional period. Most of these infants present with respiratory distress (RD) and continue to require significant respiratory ...
Yuan Shi, Hemananda Muniraman, Manoj Biniwale, Rangasamy Ramanathan   +3 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source