Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods [PDF]
, 2013 For more than two decades, scientists have been trying to replace the regulatory in vivo Draize eye test by in vitro methods, but so far only partial replacement has been achieved.
Els Adriaens +11 more
openalex +4 more sources
Antimicrobial Stewardship & Healthcare Epidemiology, 2023 Objective: To characterize personal exposures and measures of eye and respiratory tract irritation in controlled environmental chamber studies of 44 healthy adult volunteers simulating upper-bound use of peracetic acid (PAA)–based surface disinfectant ...
Pamela H. Dalton +5 more
doaj +1 more source
Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET-CAM [PDF]
Farmacia Hospitalaria, 2014 : Purpose: The objective of the study is to provide toxicological information through the HET-CAM test of Fluconazole and Voriconazole eye drops prepared commonly in Pharmacy Servi - ces for the treatment of fungal keratitis.
A. Fernández-Ferreiro +5 more
doaj +1 more source
Measurement of environmental tobacco smoke exposure among adults with asthma. [PDF]
, 2001 Because the morbidity and mortality from adult asthma have been increasing, the identification of modifiable environmental exposures that exacerbate asthma has become a priority. Limited evidence suggests that exposure to environmental tobacco smoke (ETS)
Blanc, PD +4 more
core +2 more sources
ESAC Opinion on the SkinEthic™ Human Corneal Epithelium (HCE) Eye Irritation Test (EIT) [PDF]
, 2016 ESAC, the EURL ECVAM Scientific Advisory Committee, advises EURL ECVAM on scientific issues. Its main role is to conduct independent peer review of validation studies of alternative test methods and to assess their scientific validity for a given purpose.
ALLEN Dave +15 more
core +1 more source
Toxics, 2023 The sustained growth of the market for ophthalmic medical devices has increased the demand for alternatives to animal testing for the evaluation of eye irritation.
Yang-Jee Kim +7 more
doaj +1 more source
Analysis of the pathogenic factors and management of dry eye in ocular surface disorders [PDF]
, 2017 The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin,
Albietz +14 more
core +1 more source
Further optimisation of a macromolecular ocular irritation test (OptiSafeTM)
Cutaneous and Ocular Toxicology, 2023 Purpose OptiSafeTM (OS) is a shelf stable, nonanimal test for ocular irritation. A recent database search found that half of the OS false positive (FP) materials were associated with reactive oxygen chemistries but were not eye irritants in vivo (based ...
Stewart Lebrun +3 more
semanticscholar +1 more source
TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment [PDF]
Iranian Journal of Veterinary Medicine, 2019 Background: The safety evaluations of sunscreens containing Titanium Dioxide-Nanoparticles (TiO2-NPs) were done by dermal exposure, acute dermal and eye irritation/corrosion, and skin sensitization according to the guideline for Organization for Economic
Seyedeh Maedeh Jafari +4 more
doaj +1 more source
Retrospective Evaluation of the Eye Irritation Potential of Agrochemical Formulations
bioRxiv, 2023 While multiple in vitro eye irritation methods have been developed and adopted as OECD health effects test guidelines, only one is considered a complete replacement for the in vivo rabbit eye test for classification and labelling for eye irritation ...
N. Choksi +17 more
semanticscholar +1 more source