Results 91 to 100 of about 105,778 (297)

Ocular Metastasis in Lung Cancer: a Retrospective Analysis in a Single Chinese Hospital and Literature Review

Chinese Journal of Lung Cancer, 2017
Background and objective Eye is a rare site of lung cancer metastasis, and ocular metastasis is one of the largest challenges to cancer patients' quality of life (QOL).
Yan XU, Yiduo SUN, Jing ZHAO, Minjiang CHEN, Lina JIANGDE, Longyun LI, Wei ZHONG, Mengzhao WANG   +7 more
doaj   +1 more source

Incidental finding of double nodular microscopic hyperplasia versu adenoma of the retinal pigment epithelium in an eye eviscerated for phthisis bulbi

, 2010
Neoplasms of the retinal pigment epithelium (RPE) are very rare and can clinically simulate choroidal melanoma. The clinical, histopathological and immunohistochemical features of incidental double pseudo-neoplastic proliferation of the RPE in an ...
S. Rahimi, CRUCIANI, Filippo, S. Abdolrahimzadeh, F. Garzione   +3 more
core  

Expressão gênica e proteica das isoformas A e B do receptor de progesterona, de p53 e de p21 em miométrio e leiomioma uterino [PDF]

, 2010
Os leiomiomas são neoplasias benignas comuns do sistema reprodutivo feminino e são encontrados em até 50% das mulheres em idade reprodutiva. As causas e os mecanismos de desenvolvimento desse tumor não estão bem estabelecidos; eventuais descontroles nos ...
Lora, Vanessa, Vanessa Lora
core  

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

, 2018
[Display omitted] Carcinogenesis has a multifactorial etiology, and the underlying molecular pathogenesis is still not entirely understood, especially for eye cancers. Primary malignant intraocular neoplasms are relatively rare, but delayed detection and
Ryan A. Gallo, Wensi Tao, David Tse, Tse, David, Michelle G. Zhang, Doddapaneni, Ravi, Ravi Doddapaneni, Daniel Pelaez, Lee, John Y, Pelaez, Daniel, Zhang, Michelle G, John Y. Lee, Gallo, Ryan A, Tao, Wensi   +13 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Multiple familial trichoepithelioma: confirmation via dermoscopy

Dermatology Practical & Conceptual, 2016
Trichoepitheliomas are uncommon benign adnexal neoplasms that originate from the hair follicles. Multiple familial trichoepithelioma constitute an autosomal dominant disease characterized by the appearance of multiple flesh-colored, symmetrical papules ...
Cristián Patricio Navarrete-Dechent, Shirin Bajaj, Ashfaq A. Marghoob, Sergio González, Daniel Muñoz   +4 more
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Quadruple Neoplasms following Radiation Therapy for Congenital Bilateral Retinoblastoma

, 2017
<b><i>Purpose:</i></b> The aim of this study was to describe a 34-year-old male with hereditary bilateral retinoblastoma treated with radiotherapy as a child who developed 4 distinct tumors within the radiation field. <b><
Gabriel Zada, Jonathan W. Kim, Maria E. Sibug Saber, Linda J. Szymanski, John L. Go, Kyle M. Hurth, Narsing Rao   +6 more
core   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source