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Protein and polypeptide mediated delivery to the eye
Advanced Drug Delivery Reviews, 2022Hybrid or recombinant protein-polymers, peptide-based biomaterials, and antibody-targeted therapeutics are widely explored for various ocular conditions and vision correction. They have been noted for their potential biocompatibility, potency, adaptability, and opportunities for sustained drug delivery. Unique to peptide and protein therapeutics, their
Sara Aly, Attia, J Andrew, MacKay
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Absolute Quantification of Proteins in the Eye of Drosophila melanogaster
Proteomics, 2020 Absolute (molar) quantification of proteins determines their molar ratios in complexes, networks and metabolic pathways. We employed MS Western workflow to determine molar abundances of proteins potentially critical for morphogenesis and ...
Bharath Kumar Raghuraman +2 more
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Pax proteins and eye development
Current Opinion in Neurobiology, 1996Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions.
R, Macdonald, S W, Wilson
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A novel Eyes Absent 2 protein is expressed in the human eye
Gene, 2002The Drosophila eyes absent (eya) gene has a role in regulating cell death and/or differentiation and is expressed throughout development. We evaluated the transcripts and proteins encoded by one of the human homologues of Drosophila eya coined Eyes Absent 2 (EYA2).
Brian E, Fee +2 more
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A ligand's-eye view of protein similarity
Nature Methods, 2013Classification of proteins by ligand binding similarity offers an alternative approach to evolutionary methods for organizing and understanding biology, allowing new insights into protein function and physiological signal transduction.
Gerard J P, van Westen +1 more
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Dityrosine formation in the proteins of the eye lens
Current Eye Research, 1992The presence of dityrosine crosslinks in the proteins of the lens is a subject of some debate. We have investigated the formation of dityrosine in the lens proteins, the crystallins, through reactions mediated by reactive oxygen species, as well as through direct photolysis of proteins in the UVB region.
P, Guptasarma, D, Balasubramanian
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A ligand’s-eye view of protein binding
Journal of Computer-Aided Molecular Design, 2008Docking tools created for structure-based design and virtual screening have also been used to automate ligand alignment for comparative molecular field analysis (CoMFA). Models based on such alignments have been compared with those obtained based solely on shared ligand substructures, but such comparisons have generally failed to distinguish between ...
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Some problems of protein chemistry of the eye
Documenta Ophthalmologica, 1951Proteins are substances on which the organic composition and structure of the cell depends. The protein concentration of the crystallin lens is higher than that of any other organ of the body. This predominance of proteins in the lens' substance points clearly towards the cardinal role they play in the metabolism of this organ.
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An Eye-Opener to Protein Structures
Complexus, 2002During the last 30 years of protein research, the main emphasis has been given to crystallographic details, while the very basics of polymer statistics have largely been ignored. This has resulted in a major detail being overlooked: the closed loops of the size dictated by the polypeptide chain flexibility, of which the globular proteins are actually ...
Igor N. Berezovsky +3 more
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A.M.A. Archives of Ophthalmology, 1954
OF THE proteins which are present in the vitreous body, the gelatinous material seems to be most significant. It has been termed vitrein,1or residual protein,2and a recent preparation of the structural protein has been called vitrosin.2Krause1purified the protein by filtration, followed by treatment with papain, and recorded some data on its chemical ...
R G, YOUNG, H H, WILLIAMS
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OF THE proteins which are present in the vitreous body, the gelatinous material seems to be most significant. It has been termed vitrein,1or residual protein,2and a recent preparation of the structural protein has been called vitrosin.2Krause1purified the protein by filtration, followed by treatment with papain, and recorded some data on its chemical ...
R G, YOUNG, H H, WILLIAMS
openaire +2 more sources