Enhancer of zeste homolog 2 (Ezh2) is required in mouse Isl1-expressing progenitors for proper development of cardiac and skeletal hindlimb structures [PDF]
Biology OpenHamna Ammar +4 more
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Expression of EZH2 and H3K27me3 predicts tumor biology of urothelial carcinoma
Indian Journal of Pathology and Microbiology, 2023 Background: Enhancer of zeste homolog 2 (EZH2) is one of the major epigenetic modifiers involved in the transcriptional repression of target genes through trimethylation of H3K27 (lysine 27 residue of histone H3).
Rasheeda Mohamedali +5 more
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Cancer Biology & Therapy, 2022 Radiation resistance poses a major clinical challenge in breast cancer (BC) treatment, but little is known about how long noncoding RNA (lncRNA) may regulate this phenomenon. Here, we reported that DUXAP8 was highly expressed in radioresistant BC tissues,
Changjiang Lei +7 more
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EZH2-miRNA Positive Feedback Promotes Tumor Growth in Ovarian Cancer
Frontiers in Oncology, 2021 Enhancer of zester homolog 2 (EZH2), a histone methyl transferase that mediates H3K27me3 through polycomb repressive complex 2 (PRC2), is overexpressed in ovarian cancer and promotes malignant proliferation.
Ting Liu +4 more
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Frontiers in Immunology, 2022 ObjectivesEnhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that plays an essential role in immune system development and autoimmune diseases. This study aimed to characterize the role of EZH2 in the pathogenesis of primary Sjögren’s syndrome
Chengmei He +10 more
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Investigation of the effect of CA IX enzyme inhibition on the EZH2 gene and histone 3 modifications
Türk Biyokimya Dergisi, 2023 Colon cancer is the most common gastrointestinal cancer worldwide with high morbidity and mortality rates. The main purpose of our study is to elucidate the interaction mechanism of the H+ ion concentration effect in the CO2/HCO3 − buffer system of tumor-
Karakus İbrahim, Guler Özen Özensoy
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Regulatory roles of alternative splicing at Ezh2 gene in mouse oocytes
Reproductive Biology and Endocrinology, 2022 Background Enhancer of zeste homologue 2 (EZH2), the core member of polycomb repressive complex 2 (PRC2), has multiple splicing modes and performs various physiological functions.
Shi-meng Guo +8 more
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Inhibition of GSK 3β activity is associated with excessive EZH2 expression and enhanced tumour invasion in nasopharyngeal carcinoma. [PDF]
PLoS ONE, 2013 BACKGROUND:Enhancer of zeste homolog 2 (EZH2) has been shown to contribute to tumour development and/or progression. However, the signalling pathway underlying the regulation of EZH2 in nasopharyngeal carcinoma (NPC) remains unclear.
Renqiang Ma +9 more
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Weaver Syndrome: A Rare Cause of Neonatal Macrosomia and Dysmorphism. A Case Report. [PDF]
Batna Journal of Medical SciencesWeaver syndrome is a rare genetic disorder characterized by abnormally excessive growth both in utero and postnatally. It is associated with a mutation in the EZH2 gene, which leads to accelerated bone development and other clinical manifestations such
Fadila BENDAOUD, Hemza GUELLOUH
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Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]
Journal of Genetic Resources, 2016 Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari +3 more
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