Results 11 to 20 of about 283,616 (206)
Diabetes is one of the fastest growing diseases all over the world. However, the current therapeutic strategies have not been able to stop neither its progressive course nor its complications. One possible explanation might be that the diabetes diagnosis
Matías Re
doaj +1 more source
Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants
The severe acute respiratory syndrome (SARS) coronavirus 2 (CoV-2) variant Omicron spread more rapid than the other variants of SARS-CoV-2 virus. Mutations on the Spike (S) protein receptor-binding domain (RBD) are critical for the antibody resistance ...
Clauber Henrique Souza da Costa +3 more
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Background Currently there is a high prevalence of humor disorders such as anxiety and depression throughout the world, especially concerning advanced age patients. Aniba riparia (Nees) Mez.
Sócrates Golzio dos Santos +9 more
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Reacciones adversas de los fármacos en los equinos
Artículo originalmente publicado en:Sumano López H, Lizárraga Madrigal I, Ocampo Camberos L, Obregón Jurgens K. Reacciones adversas de los fármacos en los equinos. Veterinaria México.
H. S. López +3 more
semanticscholar +1 more source
A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
core +2 more sources
Synthesis and antimycobacterial evaluation of new gem- difluorohydrazides
Several gem-difluorohydrazides were prepared by the addition of nitrogen nucleophiles to N-acetyl-2,2-gem-difluoroxindoles substituted in position 5. Initially, commercial isatin was N-acetylated using acetic anhydride.
Frederico S. C. Branco +4 more
doaj +1 more source
Symposium 7: Pharmacological algotuhm in diabetes mellitus type 2 without previous events
Diabetes in the world is growing by leaps and bounds, according to I.D.F. more than 450 million people suffer from Diabetes and the prognosis is not very promising.
Pablo Javier Ávila
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Spectroscopic and Theoretical Study of CuI Binding to His111 in the Human Prion Protein Fragment 106-115 [PDF]
The ability of the cellular prion protein (PrPC) to bind copper in vivo points to a physiological role for PrPC in copper transport. Six copper binding sites have been identified in the nonstructured N-terminal region of human PrPC.
Alberto Vela +12 more
core +2 more sources
Twenty new 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition in vitro was evaluated in mouse peritoneal macrophages, HEK-293 cells transfected with hP2X7R (dye uptake assay), and ...
Daniel T. G. Gonzaga +16 more
doaj +1 more source
AbstractThe Portuguese Society of Rheumatology and the Portuguese Society of Pulmonology have updated the guidelines for the diagnosis and treatment of latent tuberculosis infection (LTBI) and active tuberculosis (ATB) in patients with inflammatory joint diseases (IJD) that are candidates to therapy with tumour necrosis factor alpha (TNFα) antagonists.
João Eurico Fonseca +7 more
openaire +2 more sources

