Results 141 to 150 of about 6,815,038 (214)

Photonic Applications of Betanin. [PDF]

Molecules
Harvey PD.
europepmc   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

Natural Product-Based Upconversion-Downshifting Photosensitizers in Photodynamic Therapy. [PDF]

Pharmaceuticals (Basel)
Li X, Law SK, Leung AWN, Li M, Xu C.
europepmc   +1 more source

Molecular dynamics simulations and fluorescence spectroscopy suggest reduced tryptophan‐to‐heme energy transfer facilitates lignin degradation in ClassII peroxidases

The FEBS Journal, EarlyView.
In lignin peroxidase and versatile peroxidase, low FRET from buried Trp to heme promotes long‐range electron transfer (LRET) from substrate to heme. This efficient electron flow is facilitated by reduced FRET competition. This mechanism likely evolved to enable the effective degradation of bulky, high‐redox‐potential lignin that cannot reach the enzyme'
Yi Ren, Dale Ang, Haluk Ertan, Anne Poljak, Janice R. Aldrich‐Wright, Wallace J. Bridge, Khawar Sohail Siddiqui   +6 more
wiley   +1 more source

Structural heterogeneity of iron-sulfur cluster scaffold protein IscU: Metamorphic or partially folded? [PDF]

Struct Dyn
Na J, Jeong M, Kim JH.
europepmc   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source

Triplet Energy Transfer Strategy for Visible Light Activation of Bio-Based Oxime Esters in Photopolymerization and 3D Printing. [PDF]

Small
Yang K, Dietlin C, Ohl C, Manivel M, Morlet-Savary F, Schmitt M, Audran G, Joly JP, Zhang J, Xiao P, Lalevée J.   +10 more
europepmc   +1 more source

Structural and functional insights into rhodopsin‐like and secretin‐like GPCR–arrestin interactions and regulation

The FEBS Journal, EarlyView.
Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta, Annette G. Beck‐Sickinger   +1 more
wiley   +1 more source

Functional Activity of TDP-43: A Direct Biomarker for ALS. [PDF]

Biosensors (Basel)
Sonkar KS, Levi D'Ancona V, Cramp J, Shilling H, Giles E, Howell-Bray T, Fillingham B, Cudkowicz ME, Nath A, Rothstein JD, Bowser R, Borroni B, Berry JD, Sadri-Vakili G, Buratti E, Thrippleton IP.   +15 more
europepmc   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source