Results 101 to 110 of about 10,499,655 (247)

Computer Simulation of Membrane Tubulation by EFC F-BAR Domain Lattices [PDF]

Biophysical Journal, 2012
Cells are dynamically sculpted into many types of compartments by cellular membranes, in some cases with the help of BAR domain proteins. BAR domain proteins act under in vitro conditions are found to induce formation of tubules. We have seen in coarse-grained molecular dynamics simulation stretching over 100 microseconds how a flat membrane is curved ...
Yu, Hang, Schulten, Klaus, Yin, Ying, Arkhipov, Anton   +3 more
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Computer Simulations of how EFC F-BAR Domain Lattices Sculpt Membranes [PDF]

Biophysical Journal, 2011
Biological cells are dynamically sculpted into compartments by cellular membranes. For example, in vitro experiments BAR domains induce tubule formation from lipid liposomes. Previous simulations showed how different lattice arrangements of N-BAR domains shape membrane into tubules (Yin, Arkhipov, and Schulten, 2009).
Yu, Hang, Klaus, Schulten
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Heavy-to-light scalar form factors from Muskhelishvili–Omnès dispersion relations

European Physical Journal C: Particles and Fields, 2018
By solving the Muskhelishvili–Omnès integral equations, the scalar form factors of the semileptonic heavy meson decays $$D\rightarrow \pi \bar{\ell }\nu _\ell $$ D→πℓ¯νℓ , $$D\rightarrow {\bar{K}} \bar{\ell }\nu _\ell $$ D→K¯ℓ¯νℓ , $${\bar{B}}\rightarrow
D. -L. Yao, P. Fernandez-Soler, M. Albaladejo, F. -K. Guo, J. Nieves   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Microwave Kinetic Inductance Detector Made of Molecular Beam Epitaxy (MBE)-Grown MgB2 Film

Nanomaterials
We present a MgB2-based Microwave Kinetic Inductance Detector (MKID) featuring a quality factor Qi ~ 105 and noise equivalent power NEP ~ 10−14 W/Hz at 2 K.
Ariel Roitman, Corentin Pfaff, Thomas Hauet, Avner Shaulov, Yosef Yeshurun   +4 more
doaj   +1 more source

Going on a (Membrane) Bender to the F-BAR

Developmental Cell, 2011
This study is a personal favorite because it simplified the field and proposed an elegant model of how actin and membranes work together in endocytic trafficking. A group of proteins containing FCH domains (Fes/CIP4 homology) were discovered to have extended homology with the banana-shaped alpha helical BAR domain and renamed F-BAR proteins.
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source