Results 31 to 40 of about 1,206,903 (162)

Simulation of Membrane Sculpting by EFC F-BAR Domain Lattices [PDF]

Biophysical Journal, 2010
Cells, during cellular morphogenesis, are dynamically sculpted into different compartments by membranes with the help of proteins. The BAR domain is one of the conserved protein domains that is involved in shaping cellular membranes in vivo, and is observed to induce tubule formation from liposomes in vitro.
Yu, Hang, Yin, Ying, Arkhipov, Anton, Schulten, Klaus   +3 more
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Molecular basis for SH3 domain regulation of F-BAR–mediated membrane deformation [PDF]

Proceedings of the National Academy of Sciences, 2010
Members of the Bin/amphiphysin/Rvs (BAR) domain protein superfamily are involved in membrane remodeling in various cellular pathways ranging from endocytic vesicle and T-tubule formation to cell migration and neuromorphogenesis. Membrane curvature induction and stabilization are encoded within the BAR or Fer-CIP4 homology-BAR (F-BAR) domains, α-helical
Rao, Yijian, Ma, Qingjun, Vahedi-Faridi, Ardeschir, Sundborger, Anna, Pechstein, Arndt, Puchkov, Dmytro, Luo, Lin, Shupliakov, Oleg, Saenger, Wolfram, Haucke, Volker   +9 more
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F-BAR/EFC Domain Proteins: Some Assembly Required [PDF]

Developmental Cell, 2015
Polymeric spirals of crescent-shaped BAR-domain superfamily proteins are touted to girdle eukaryotic phospholipid bilayers into narrow tubules for trafficking and membrane remodeling events. But McDonald et al. (2015) in this issue of Developmental Cell question whether this broadly held view and conceptually appealing mechanism for membrane sculpting ...
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An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads

Cell Reports, 2021
Summary: Membrane curvature recruits Bin-Amphiphysin-Rvs (BAR)-domain proteins and induces local F-actin assembly, which further modifies the membrane curvature and dynamics. The downstream molecular pathway in vivo is still unclear. Here, we show that a
Tushna Kapoor, Pankaj Dubey, Seema Shirolikar, Krishanu Ray   +3 more
doaj   +1 more source

Computer Simulation of Membrane Tubulation by EFC F-BAR Domain Lattices [PDF]

Biophysical Journal, 2012
Cells are dynamically sculpted into many types of compartments by cellular membranes, in some cases with the help of BAR domain proteins. BAR domain proteins act under in vitro conditions are found to induce formation of tubules. We have seen in coarse-grained molecular dynamics simulation stretching over 100 microseconds how a flat membrane is curved ...
Yu, Hang, Schulten, Klaus, Yin, Ying, Arkhipov, Anton   +3 more
openaire   +1 more source

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

eLife, 2023
The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and plays a key role in attaching the cytokinetic ring (CR) to the plasma membrane (PM).
Rahul Bhattacharjee, Aaron R Hall, MariaSanta C Mangione, Maya G Igarashi, Rachel H Roberts-Galbraith, Jun-Song Chen, Dimitrios Vavylonis, Kathleen L Gould   +7 more
doaj   +1 more source

The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis

Cell Reports, 2016
F-BAR proteins link cellular membranes to the actin cytoskeleton in many biological processes. Here we investigated the function of the Schizosaccharomyces pombe Imp2 F-BAR domain in cytokinesis and find that it is critical for Imp2’s role in contractile
Nathan A. McDonald, Yoshimasa Takizawa, Anna Feoktistova, Ping Xu, Melanie D. Ohi, Craig W. Vander Kooi, Kathleen L. Gould   +6 more
doaj   +1 more source

Computer Simulations of how EFC F-BAR Domain Lattices Sculpt Membranes [PDF]

Biophysical Journal, 2011
Biological cells are dynamically sculpted into compartments by cellular membranes. For example, in vitro experiments BAR domains induce tubule formation from lipid liposomes. Previous simulations showed how different lattice arrangements of N-BAR domains shape membrane into tubules (Yin, Arkhipov, and Schulten, 2009).
Yu, Hang, Klaus, Schulten
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Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. [PDF]

, 2018
This is the final version of the article. Available from International Union of Crystallography via the DOI in this record.SRGAP2 (Slit-Robo GTPase-activating protein 2) is a cytoplasmic protein found to be involved in neuronal branching, restriction of ...
Guez-Haddad, J, Isupov, MN, Opatowsky, Y, Sporny, M, Waterman, DG   +4 more
core   +1 more source

How Synaptotagmin I, N-BAR and F-BAR Domains Generate Membrane Curvature [PDF]

Biophysical Journal, 2015
Protein-induced membrane curving governs many cellular processes, including cell division, growth and cell-cell communication. In order to unravel the mechanism for how membrane curvature occurs driven by the proteins, one needs to have detailed molecular pictures on the key membrane-protein interactions and protein-protein interactions.
Wu, Zhe, Yu, Hang, Arkhipov, Anton, Yin, Ying, Schulten, Klaus   +4 more
openaire   +1 more source