Results 31 to 40 of about 1,113,401 (243)
Cell Reports, 2021 Summary: Membrane curvature recruits Bin-Amphiphysin-Rvs (BAR)-domain proteins and induces local F-actin assembly, which further modifies the membrane curvature and dynamics. The downstream molecular pathway in vivo is still unclear. Here, we show that a
Tushna Kapoor +3 more
doaj +1 more source
Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. [PDF]
Proc Natl Acad Sci U S A, 2012 Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that plays important roles in activity-dependent bulk endocytosis and neuronal morphogenesis. While syndapin I is an in vitro phosphoprotein, it is not known to be phosphorylated in neurons.
Quan A +8 more
europepmc +6 more sources
Computer Simulation of Membrane Tubulation by EFC F-BAR Domain Lattices [PDF]
Biophysical Journal, 2012 Cells are dynamically sculpted into many types of compartments by cellular membranes, in some cases with the help of BAR domain proteins. BAR domain proteins act under in vitro conditions are found to induce formation of tubules. We have seen in coarse-grained molecular dynamics simulation stretching over 100 microseconds how a flat membrane is curved ...
Yu, Hang +3 more
openaire +1 more source
eLife, 2023 The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and plays a key role in attaching the cytokinetic ring (CR) to the plasma membrane (PM).
Rahul Bhattacharjee +7 more
doaj +1 more source
Cell Reports, 2016 F-BAR proteins link cellular membranes to the actin cytoskeleton in many biological processes. Here we investigated the function of the Schizosaccharomyces pombe Imp2 F-BAR domain in cytokinesis and find that it is critical for Imp2’s role in contractile
Nathan A. McDonald +6 more
doaj +1 more source
Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. [PDF]
, 2018 This is the final version of the article. Available from International Union of Crystallography via the DOI in this record.SRGAP2 (Slit-Robo GTPase-activating protein 2) is a cytoplasmic protein found to be involved in neuronal branching, restriction of ...
Guez-Haddad, J +4 more
core +1 more source
Computer Simulations of how EFC F-BAR Domain Lattices Sculpt Membranes [PDF]
Biophysical Journal, 2011 Biological cells are dynamically sculpted into compartments by cellular membranes. For example, in vitro experiments BAR domains induce tubule formation from lipid liposomes. Previous simulations showed how different lattice arrangements of N-BAR domains shape membrane into tubules (Yin, Arkhipov, and Schulten, 2009).
Yu, Hang, Klaus, Schulten
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How Synaptotagmin I, N-BAR and F-BAR Domains Generate Membrane Curvature [PDF]
Biophysical Journal, 2015 Protein-induced membrane curving governs many cellular processes, including cell division, growth and cell-cell communication. In order to unravel the mechanism for how membrane curvature occurs driven by the proteins, one needs to have detailed molecular pictures on the key membrane-protein interactions and protein-protein interactions.
Wu, Zhe +4 more
openaire +1 more source
The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. [PDF]
J Cell Biol, 2010 Robust cell–cell adhesion is critical for tissue integrity and morphogenesis, yet little is known about the molecular mechanisms controlling cell–cell junction architecture and strength. We discovered that SRGP-1 is a novel component of cell–cell junctions in Caenorhabditis elegans, localizing via its F-BAR (Bin1, Amphiphysin, and RVS167) domain and a ...
Zaidel-Bar R +5 more
europepmc +4 more sources
Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7
Nature Communications, 2019 The Bin/Amphiphysin/Rvs167 (BAR) domain superfamily, which includes FCH-BAR (F-BAR) domain proteins are membrane-sculpting proteins. Here the authors combine a range of techniques and show that the F-BAR domain of growth-arrest specific protein 7 (GAS7 ...
Kyoko Hanawa-Suetsugu +19 more
doaj +1 more source