Results 91 to 100 of about 25,145 (258)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Smoothed $f$-Divergence Distributionally Robust Optimization

, 2023
In data-driven optimization, sample average approximation (SAA) is known to suffer from the so-called optimizer's curse that causes an over-optimistic evaluation of the solution performance. We argue that a special type of distributionallly robust optimization (DRO) formulation offers theoretical advantages in correcting for this optimizer's curse ...
Liu, Zhenyuan, Van Parys, Bart P. G., Lam, Henry   +2 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

New Improvements of the Jensen–Mercer Inequality for Strongly Convex Functions with Applications

Axioms
In this paper, we use the generalized version of convex functions, known as strongly convex functions, to derive improvements to the Jensen–Mercer inequality. We achieve these improvements through the newly discovered characterizations of strongly convex
Muhammad Adil Khan, Slavica Ivelić Bradanović, Haitham Abbas Mahmoud   +2 more
doaj   +1 more source

Extremal Mechanisms for Local Differential Privacy [PDF]

, 2015
Local differential privacy has recently surfaced as a strong measure of privacy in contexts where personal information remains private even from data analysts.
Kairouz, Peter, Oh, Sewoong, Viswanath, Pramod   +2 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

New Information Inequalities in Terms of Variational Distance and its Application

Journal of New Results in Science, 2016
In this work, new information inequalities are obtained and characterized on new generalized f- divergence (introduced by Jain and Saraswat (2012)) in terms of the Variational distance and these inequalities have been taken for evaluating some new ...
K. C. Jain, Praphull Chhabra
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Restricted phase space thermodynamics of charged static and charged rotating black holes in f(R) gravity

European Physical Journal C: Particles and Fields
In this work, we study the restricted phase space thermodynamics (RPST) of charged static and rotating black holes in f(R) gravity. By keeping the cosmological constant fixed and introducing the central charge C with its conjugate chemical potential ...
Amijit Bhattacharjee, Prabwal Phukon
doaj   +1 more source

Geometric IR subtraction for final state real radiation

Journal of High Energy Physics, 2018
A scheme is proposed for the subtraction of soft and collinear divergences present in massless final state real emission phase space integrals. The scheme is based on a local slicing procedure which utilises the soft and collinear factorisation ...
Franz Herzog
doaj   +1 more source