Results 51 to 60 of about 16,274,002 (260)

A perfectoid duality between M-theory and F-theory

open access: yesNuclear Physics B
We present a non-singular, definition-level formulation of F-theory by replacing the traditional shrinking-fiber limit of M-theory with compactification on a tower-completed circle described using perfectoid geometry and condensed mathematics.
Arshid Shabir   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Orientifold limits of singular F-theory vacua

open access: yesNuclear Physics B, 2020
We construct global orientifold limits of singular F-theory vacua whose associated gauge groups are SO(3), SO(5), SO(6), F4, SU(4), and Spin(7). For each limit we show a universal tadpole relation is satisfied, which is a homological identity whose ...
James Fullwood, Dongxu Wang
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

F-theory with hyperelliptic fibrations

open access: yesJournal of High Energy Physics
We discuss the role of hyperelliptic fibrations in F-theory. For each even integer n we give a noncompact Calabi-Yau threefold X containing a hyperelliptically fibered surface Y, such that X and Y are homotopy equivalent and c 2(X) = n.
E. Ballico   +3 more
doaj   +1 more source

Vortex spin-torque oscillator stabilized by phase locked loop using integrated circuits

open access: yesAIP Advances, 2017
Spin-torque nano-oscillators (STO) are candidates for the next technological implementation of spintronic devices in commercial electronic systems.
Martin Kreissig   +11 more
doaj   +1 more source

Orders of vanishing and U(1) charges in F-theory

open access: yesJournal of High Energy Physics, 2022
Many interesting questions about F-theory models, including several concerning the F-theory swampland, involve massless matter charged under U(1) gauge symmetries. It is therefore important to better understand the geometric properties of F-theory models
Nikhil Raghuram, Andrew P. Turner
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Holomorphic anomalies, fourfolds and fluxes

open access: yesJournal of High Energy Physics, 2022
We investigate holomorphic anomalies of partition functions underlying string compactifications on Calabi-Yau fourfolds with background fluxes. For elliptic fourfolds the partition functions have an alternative interpretation as elliptic genera of N = 1 ...
Seung-Joo Lee   +3 more
doaj   +1 more source

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