Results 51 to 60 of about 383,430 (227)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Image Matching by Using Fuzzy Transforms
We apply the concept of Fuzzy Transform (for short, F-transform) for improving the results of the image matching based on the Greatest Eigen Fuzzy Set (for short, GEFS) with respect to max-min composition and the Smallest Eigen Fuzzy Set (for short, SEFS)
Ferdinando Di Martino, Salvatore Sessa
doaj +1 more source
The main ideas of F-transform came from representing expert rules. It would be therefore reasonable to expect that the more accurately the membership functions describe human reasoning, the more successful will be the corresponding F-transform formulas ...
Olga Kosheleva +2 more
doaj +1 more source
Rotating 5D-Kaluza-Klein Space-Times from Invariant Transformations [PDF]
Using invariant transformations of the five-dimensional Kaluza-Klein (KK) field equations, we find a series of formulae to derive axial symmetric stationary exact solutions of the KK theory starting from static ones.
D. Rasheed +24 more
core +2 more sources
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Generalized integral Laplace transform and its application to solving some integral equations
We present integral transforms $\widetilde {\mathcal L}\left\{f(t);x\right\}$ and $\widetilde {\mathcal L}_{\gamma_1,\gamma_2,\gamma} \left\{f(t);x\right\}$, generalizing the classical Laplace transform.
Svetlana M Zaikina
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Injectivity sets of the spherical mean operator with respect to the Bessel convolution [PDF]
Let $C_\natural$ be the set of all even continuous functions on the real axis, $E$ be a non-empty set on $(0,+\infty)$, $\mathcal{R} f(x,t)$ be the spherical mean of the function $f\in C_\natural$ with center at the point $x\in E$ and radius $t>0 ...
Krasnoschekikh, Gleb Vitalievich +1 more
doaj +1 more source
Canonical transformations in quantum mechanics
This paper presents the general theory of canonical transformations of coordinates in quantum mechanics. First, the theory is developed in the formalism of phase space quantum mechanics.
Anderson +42 more
core +1 more source

