Results 71 to 80 of about 1,898 (145)

Bioenergetic profiles and respiratory control in mitochondrial physiology: Precision analysis of oxidative phosphorylation

Experimental Physiology, Volume 111, Issue 1, Page 179-211, 1 January 2026.
Abstract Oxidative phosphorylation (OXPHOS) is fundamental to mitochondrial function. Respirometry with living cells provides limited information compared to precision OXPHOS analysis with mitochondrial preparations, including isolated mitochondria, tissue homogenates, permeabilized tissues, and permeabilized cells.
Alba Timón‐Gómez, Carolina Doerrier, Zuzana Sumbalová, Luiz F. Garcia‐Souza, Eleonora Baglivo, Luiza H. D. Cardoso, Erich Gnaiger   +6 more
wiley   +1 more source

Primary‐Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early‐stage muscle dysfunction remain unclear.
Xiaolin Li, Miranda van der Ende, Hanneke Moonen, Rogier Plas, Susanne Lotstra, Mieke Poland, Jaap Keijer, Renger F. Witkamp, Tjarda van Heek, Sander Grefte, Klaske van Norren, the COMUNEX group, Flip M. Kruyt, Colin Sietses, Gabie M. de Jong, Roland M. H. G. Mollen, Joé L. P. Kolkert, Dik Snijdelaar, Marlieke Visser, Jaap Dronkers   +19 more
wiley   +1 more source

Understanding structure, function, and mutations in the mitochondrial ATP synthase

Microbial Cell, 2015
The mitochondrial ATP synthase is a multimeric enzyme complex with an overall molecular weight of about 600,000 Da. The ATP synthase is a molecular motor composed of two separable parts: F1 and Fo. The F1 portion contains the catalytic sites for ATP
Ting Xu, Vijayakanth Pagadala, David M. Mueller   +2 more
doaj   +1 more source

Neuroprotective effects of ATPase inhibitory factor 1 preventing mitochondrial dysfunction in Parkinson's disease

Scientific Reports, 2022
Mitochondrial dysfunction is a key element in the progression of Parkinson’s disease (PD). The inefficient operation of the electron transport chain (ETC) impairs energy production and enhances the generation of oxidative stress contributing to the loss ...
InHyeok Chung, Han-A Park, Jun Kang, Heyyoung Kim, Su Min Hah, Juhee Lee, Hyeon Soo Kim, Won-Seok Choi, Ji Hyung Chung, Min-Jeong Shin   +9 more
doaj   +1 more source

A simulation study on the role of mitochondria‐sarcoplasmic reticulum Ca2+ interaction in cardiomyocyte energetics during exercise

The Journal of Physiology, Volume 603, Issue 18, Page 4921-4949, September 15, 2025.
Abstract figure legend An integrated model of human ventricular myocyte with excitation‐contraction‐energetics coupling was created to systematically analyse the contribution of Ca2+ regulation of mitochondrial enzymes to cardiomyocyte functions during workload transition; i.e. exercise.
Ayako Takeuchi, Satoshi Matsuoka
wiley   +1 more source

Knocking out of the Mitochondrial Gene orf218 Using mitoTALECD Restores Cytoplasmic Male Sterility in Eggplant

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT In the alloplasmic lines of eggplant containing the cytoplasm of relative wild species, two types of cytoplasmic male sterility (CMS) are known: the pollen non‐formation (PN) type and the anther indehiscent (AI) type. The gene responsible for PN‐type CMS is presumed to be orf218, located in the mitochondrial genome.
Mai Tsujimura, Takako Shizuka, Akito Miyata, Asahi Susami, Takeo Saito, Koji Miyatake, Shin‐ichi Arimura, Hiroshi Yamagishi, Toru Terachi   +8 more
wiley   +1 more source

Quinoline ATP Synthase Inhibitors with Activity Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

ChemMedChem, Volume 20, Issue 10, May 19, 2025.
Targeting ATP synthase in Gram‐negative pathogens. Presented is the first disclosure of quinoline‐derived antibiotics inhibiting multidrug resistant Acinetobacter baumannii ATP synthase and expansion of the structure activity relationship profile of Pseudomonas aeruginosa ATP synthase inhibitors.
Katie T. Ward, Alexander P. L. Williams, Angelina L. Dennison, Lena Aamir, Darien L. Allen, Britza Chavez‐Arellano, Toni A. Marchlewski, Mars L. Zappia, Amanda L. Wolfe, P. Ryan Steed   +9 more
wiley   +1 more source

Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent

Advanced Science, Volume 12, Issue 20, May 29, 2025.
This paper summarizes the latest applications and potential mechanisms of the rare earth element gadolinium in biomedical fields, in addition to its traditional application as an MRI contrast agent, including osteogenesis, antimicrobial, antitumor, bioimaging, bioprobes, and so on.
Xingtong Pan, Menglong Hu, Likun Wu, Erfan Wei, Qiyue Zhu, Letian Lv, Xiuyun Xv, Xinyi Dong, Hao Liu, Yunsong Liu   +9 more
wiley   +1 more source

Engineered Living Energy Materials

Interdisciplinary Materials, Volume 4, Issue 3, Page 412-455, May 2025.
Engineered living energy materials (ELEMs) are nascent research frontier for enabling sustainable energy conversion and storage. These materials exhibit unique characteristics such as self‐regeneration, biodegradability, environmental response, and evolutionary adaptability. This paper overviews different energy conversion bio‐modules, summarizes their
Xinyi Yuan, Haiyi Xu, Xingwu Liu, Jicong Zhang, Jing Li, Qianyi Liang, Bolin An, Giuseppe Maria Paternò, Minyue Zhang, Yuqing Tang, Chen Zhang, Dake Xu, Chao Zhong, Ke Li, Xinyu Wang   +14 more
wiley   +1 more source

Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non‐Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production

Advanced Science, Volume 12, Issue 13, April 3, 2025.
POU3F3 is significantly upregulated in non‐small cell lung cancer (NSCLC). Activated ERK1 directly interacts with and phosphorylates POU3F3, facilitating its nuclear translocation in NSCLC cells. Within the nucleus, POU3F3 functions as a transcription factor to enhance ATP5PF expression, thereby increasing the activity of mitochondrial complex V and ...
Qi‐Gang Zeng, Le Li, Tao Chang, Yong Sun, Bin Zheng, Ling‐Na Xue, Chao‐Ling Liu, Xia‐Qing Li, Ruo‐Tong Huang, Jia‐Xin Gu, Zhao‐Rong An, Hao‐Tao Yao, Dan‐Yang Zhou, Jun Fan, Yong Dai   +14 more
wiley   +1 more source