Results 81 to 90 of about 1,898 (145)

The spatio-temporal organization of mitochondrial F1FO ATP synthase in cristae depends on its activity mode

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2020
F1FO ATP synthase, also known as complex V, is a key enzyme of mitochondrial energy metabolism that can synthesize and hydrolyze ATP. It is not known whether the ATP synthase and ATPase function are correlated with a different spatio-temporal organisation of the enzyme. In order to analyze this, we tracked and localized single ATP synthase molecules in
Salewskij, Kirill, Rieger, Bettina, Hager, Frances, Arroum, Tasnim, Duwe, Patrick, Villalta, Jimmy, Colgiati, Sara, Richter, Christian P, Psathaki, Olympia E, Enriquez, Jose Antonio, Dellmann, Timo, Busch, Karin B   +11 more
openaire   +4 more sources

Caenorhabditis elegans ATPase inhibitor factor 1 (IF1) MAI-2 preserves the mitochondrial membrane potential (Δψm) and is important to induce germ cell apoptosis.

PLoS ONE, 2017
When the electrochemical proton gradient is disrupted in the mitochondria, IF1 (Inhibitor Factor-1) inhibits the reverse hydrolytic activity of the F1Fo-ATP synthase, thereby allowing cells to conserve ATP at the expense of losing the mitochondrial ...
L P Fernández-Cárdenas, E Villanueva-Chimal, L S Salinas, C José-Nuñez, M Tuena de Gómez Puyou, R E Navarro   +5 more
doaj   +1 more source

IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat

The EMBO Journal
While mechanisms controlling uncoupling protein-1 (UCP1) in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis, it remains unclear whether F1Fo-ATP synthase function is also regulated in brown adipose tissue (BAT).
Henver S Brunetta, Anna S Jung, Fernando Valdivieso-Rivera, Stepheny C de Campos Zani, Joel Guerra, Vanessa O Furino, Annelise Francisco, Marcelo Berçot, Pedro M Moraes-Vieira, Susanne Keipert, Martin Jastroch, Laurent O Martinez, Carlos H Sponton, Roger F Castilho, Marcelo A Mori, Alexander Bartelt   +15 more
doaj   +1 more source

Ultrafast purification and reconstitution of His-tagged cysteine-less Escherichia coli F1Fo ATP synthase

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2005
His-tagged cysteine-less F1Fo ATP synthase from Escherichia coli was purified using Ni-NTA affinity chromatography. During the purification procedure the loss of total ATPase activity did not exceed 50%, and the extent of purification was about 80-fold.
Ishmukhametov, RR, Galkin, MA, Vik, SB
openaire   +4 more sources

Beneficial effect of polyphenols in COVID-19 and the ectopic F₁ F_O -ATP synthase: Is there a link? [PDF]

J Cell Biochem, 2022
Panfoli I, Esposito A.
europepmc   +1 more source

Fluid shear stress enhances proliferation of breast cancer cells via downregulation of the c-subunit of the F₁F_O ATP synthase. [PDF]

Biochem Biophys Res Commun, 2022
Park HA, Brown SR, Jansen J, Dunn T, Scott M, Mnatsakanyan N, Jonas EA, Kim Y.   +7 more
europepmc   +1 more source

An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. [PDF]

Commun Biol, 2022
Hards K, Cheung CY, Waller N, Adolph C, Keighley L, Tee ZS, Harold LK, Menorca A, Bujaroski RS, Buckley BJ, Tyndall JDA, McNeil MB, Rhee KY, Opel-Reading HK, Krause K, Preiss L, Langer JD, Meier T, Hasenoehrl EJ, Berney M, Kelso MJ, Cook GM.   +21 more
europepmc   +1 more source

Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke

Nature Communications
Mitochondrial cristae ultrastructure enables ATP synthase organization for adaptive energy production. This process is critical for regulating microglia mediated neuroinflammation in ischemic stroke pathology.
Xiao-Wen Zhang, Xiao-Ming Ye, Ran Wang, Yong-Dong Guo, Ling Li, Yang Chen, Ting-ting Liu, Xiao-Qing Zhou, Yu-Qi Wang, Zhong-Yao Li, Zhi-Yuan Lu, Zhi-Yong Du, Wei Zhou, Bo Han, Peng-Fei Tu, Qi-Xin Chen, Chun-Hong Zheng, Ke-Wu Zeng   +17 more
doaj   +1 more source

Mitochondrial F₁ F_O ATP synthase determines the local proton motive force at cristae rims. [PDF]

EMBO Rep, 2021
Rieger B, Arroum T, Arroum T, Borowski MT, Villalta J, Busch KB.   +5 more
europepmc   +1 more source

On the rotary mechanism of F1FO-ATP synthases

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Pogoryelov, Denys, Krah, Alexander, Langer, Julian, Faraldo-Gómez, José D., Meier, Thomas   +4 more
openaire   +1 more source