Results 11 to 20 of about 674 (152)

Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors

open access: yesExperimental Hematology, 2004
Genetic modification of effector lymphocytes, such as T cells and natural killer (NK) cells, is essential for many approaches to gene-based immunotherapy of cancer. However, transduction of lymphocytes has proven difficult by currently available gene transfer methods.
Roland Schroers   +2 more
exaly   +6 more sources

Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity

open access: yesJournal for ImmunoTherapy of Cancer, 2020
Background Adenovirus serotype 5 (Ad5) is a commonly used viral vector for transient delivery of transgenes, primarily for vaccination against pathogen and tumor antigens.
Tingting Zhan   +13 more
doaj   +4 more sources

Numerical Investigation and Water Tunnel Experiment for F35 Fighter Jet

open access: yesAdıyaman University Journal of Science, 2020
In this paper, a low-speed aerodynamic flow structure of the original F35 aircraft model was investigated in a closed-circuit water tunnel experiment, and the investigation was also conducted numerically by using a computational fluid dynamic (CFD) approach.
SOGUKPİNAR, Haci   +2 more
openaire   +4 more sources

XAF1 Inhibits Cell Proliferation and Induces Apoptosis 
in Human Lung Adenocarcinoma Cell Line A549 In Vitro

open access: yesChinese Journal of Lung Cancer, 2014
Background and objective XAF1 is a factor necessary to inhibit tumor cell growth. Low XAF1 expression is associated with various tumor cells. The aim of this study is to investigate the effect and the mechanism of adenovirus vector Ad5/F35 mediated X ...
Donglai CHEN   +5 more
doaj   +2 more sources

Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy

open access: yesnpj Vaccines, 2022
Strategies to augment immunity to self/neoantigens expressed by cancers are urgently needed to expand the proportion of patients benefiting from immunotherapy, particularly for GI cancers where only a fraction of patients respond to immunotherapies ...
John C. Flickinger   +10 more
doaj   +3 more sources

Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model. [PDF]

open access: yesPLoS ONE, 2013
Resistance to radiotherapy is a key limitation for the treatment of human hepatocellular carcinoma (HCC). To overcome this problem, we investigated the correlation between radioresistance and the human apurinic/apyrimidinic endonuclease (APE1), a ...
Yanping Cun   +7 more
doaj   +1 more source

External aid behavior in the recipient economy: A probit regression for Africa

open access: yesJournal of Economics and Management, 2022
Aim/purpose – External aid allocation by the donors in recent years has been fraught with instability and volatility. This has a negative consequence on the recipient economies particularly those that are highly aid-dependent.
Adediyan Aderopo Raphael   +1 more
doaj   +1 more source

Effects of Development Aid on Donor’s Exports: A Case of the Czech Republic

open access: yesReview of Economic Perspectives, 2022
The main goal of foreign aid should be the support of developing regions; however, due to the rising international requirements on the amount of provided aid, donors start to focus on the benefits aid can bring them as well.
Dufková Gabriela, Šálek Pavel
doaj   +1 more source

Proteomic analysis of seedling roots of two maize inbred lines that differ significantly in the salt stress response. [PDF]

open access: yesPLoS ONE, 2015
Salinity is a major abiotic stress that limits plant productivity and quality throughout the world. Roots are the sites of salt uptake. To better understand salt stress responses in maize, we performed a comparative proteomic analysis of seedling roots ...
Dezhou Cui   +13 more
doaj   +1 more source

Volume and Territorial Distribution of the Czech Republic’s Official Development Assistance Flows to Least Developed Countries

open access: yesReview of Economic Perspectives, 2021
Official Development Assistance (ODA) is considered one of the most important external resources of finance that can contribute to sustainable development in the Least Developed Countries (LDCs).
Kovářová Eva
doaj   +1 more source

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