Results 61 to 70 of about 674 (152)

Morphological characteristics of the cerebral cortex of a mini-pig under conditions of gene therapy after experimental stroke

Сеченовский вестник
Aim. To study the effectiveness of preventive gene therapy (within 2 days) and gene therapy in the acute phase (after 4 hours) of ischemic stroke in mini-pigs using an autologous leucoconcentrate (AutoLeuc) enriched with recombinant genes of vascular ...
Z. Z. Safiullov, A. Izmailov, V. A. Markosyan, A. E. Khomyakov, N. V. Boychuk, M. V. Nigmetzyanova, A. R. Siraeva, S. S. Targachev, V. V. Valiullin, R. R. Islamov, V. I. Pospelov   +10 more
doaj   +1 more source

Integrated Omics Analysis Reveals Flavonoid‐Mediated Resistance to Tomato Spotted Wilt Virus

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT Tomato spotted wilt virus (TSWV) poses a severe threat to global tomato production. Developing resistant cultivars requires a deeper understanding of the molecular mechanisms underlying plant‐virus interactions. In this study, we employed an intergrated transcriptomic and metabolomic analysis to investigate the defense responses of a ...
Jun Su, Yanping Liang, Lina Wang, Yingyun He, Wen Zhang, Wanfu Mu, Junxing Zhang, Yongdui Chen, Yating Liu, Yongzhong Li   +9 more
wiley   +1 more source

The Role of DNA Methylation and ZBTB Transcription Factors in Sex Differentiation, Maintenance and Heat‐Induced Masculinization in Zebrafish

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Sex differentiation, the process by which an organism develops as a male or female, can be influenced by the environment in many species. High temperature, or pollutant exposure, can lead to skewed sex‐ratios and genotype‐phenotype mismatches that can seriously threaten populations and biodiversity. Understanding the mechanisms involved in sex
Fabien Pierron, Débora Heroin, Flore Daramy   +2 more
wiley   +1 more source

N-terminally deleted forms of PrP are impaired in their ability to suppress the neurodegenerative phenotype of Tg(F35) mice.

, 2013
The genotype, number of mice, age at death, and relative expression levels PrP are shown for each transgenic line. While 0.5× expression of WT PrP greatly prolongs the lifespan of Tg(F35) mice, the N-terminal mutants have only a modest effect on lifespan,
David A. Harris (330039), Ursula Unterberger (343134), Laura Westergard (343132), Emiliano Biasini (330033), Jessie A. Turnbaugh (330034)   +4 more
core   +1 more source

The contributions of foreign aid and natural resource wealth to democratic institutions: Evidence from over 40 years of sub-Sahara Africa's history

Journal of Government and Economics
This study evaluates the influence of natural resource rents and foreign aid on democracy using panel data from 45 SSA countries from 1980 to 2021. Using five different democracy indices, six different foreign aid variables and six different natural ...
Alex O. Acheampong, John Taden
doaj   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, Volume 24, Issue 4, Page 1936-1949, April 2026.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Archeologisch bureauonderzoek Bankastraat F35 te Hengelo, gemeente Hengelo (OV)

, 2023
Laagland Archeologie heeft in maart 2023 een Archeologisch bureauonderzoek uitgevoerd aan de Bankastraat F35 te Hengelo. Het onderzoek vond plaats in verband met de ruimtelijke procedure rondom de herontwikkeling van dit gebied.
Brouwer, E.W., Ponten, A.
core   +1 more source

Escaping Constraints to Innovate: Maternal Neofunctionalization in a HoxB4 Duplicate

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 141-151, March 2026.
Whole‐genome duplication in Xenopus laevis generated duplicated Hox genes that are largely constrained in sequence and developmental expression. However, HoxB4L uniquely acquired maternal expression through cis‐regulatory and protein structural divergence, illustrating how gene duplication enables transcription factors to escape pleiotropic constraints
Júlia de Lima Carvalho, José Caetano Silva‐Filho, Janaina Lima de Oliveira   +2 more
wiley   +1 more source

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

, 2006
Heterozygous mutations in the human Kir6.2 gene (KCNJ11), the pore-forming subunit of the ATP-sensitive K(+) channel (K(ATP) channel), cause neonatal diabetes.
Proks, P, Ashcroft, FM, Njølstad, PR, Ashcroft, Frances, Girard, C, Baevre, H   +5 more
core   +1 more source

Efficient gene transfer into T lymphocytes by fiber-modified human adenovirus 5

BMC Biotechnology, 2019
Background The gene transduction efficiency of adenovirus to hematopoietic cells, especially T lymphocytes, is needed to be improved. The purpose of this study is to improve the transduction efficiency of T lymphocytes by using fiber-modified human ...
Yun Lv, Feng-Jun Xiao, Yi Wang, Xiao-Hui Zou, Hua Wang, Hai-Yan Wang, Li-Sheng Wang, Zhuo-Zhuang Lu   +7 more
doaj   +1 more source