Results 61 to 70 of about 691,826 (352)

Design and construction of test facility for evaluation of swell packers in cased and open holes [PDF]

, 2021
Tasneem Pervez, Sayyad Zahid Qamar, Maaz Akhtar, Moosa Al Kharusi   +3 more
openalex   +1 more source

Development of a thermal ionizer as ion catcher

, 2008
An effective ion catcher is an important part of a radioactive beam facility that is based on in-flight production. The catcher stops fast radioactive products and emits them as singly charged slow ions.
A. Rogachevskiy, A.J. Mol, Bayat, Berg, C.J.G. Onderwater, Clifford, Crank, Datz, Dendooven, E. Traykov, Fick, Fujioka, H.W. Wilschut, Huyse, Jungmann, Jungmann, K. Jungmann, Kirchner, Kirchner, Kirchner, L. Huisman, L. Willmann, Langmuir, Love, M. da Silva e Silva, M. Sohani, McCracken, O. Versolato, O.C. Dermois, Rossbach, S. De, Traykov, U. Dammalapati, W. Kruithof, Willmann, Wilschut, Ziegler, Ärje   +37 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The other GMP: good manufacturing practice and its importance in the validation of constructed pharmaceutical facilities [PDF]

, 2005
The work reported is part of an ongoing PhD study prompted by the particular difficulties encountered when two very different quality cultures interact (in this case Pharmaceutical industry clients and Construction industry providers).
Edge, Jerry, Greenwood, David, Render, Neil   +2 more
core  

A new experimental snow avalanche test site at Seehore peak in Aosta Valley (NW Italian Alps) - Part II: Engineering aspects [PDF]

, 2013
The estimate of the effects produced by the impact of a snow avalanche against an obstacle is of the utmost importance in designing safe mountain constructions.
Ammann, B. Chiaia, B. Frigo, Christen, Consiglio Superiore dei Lavori Pubblici, D. Godone, D. Viglietti, Dufour, E. Bovet, E. Ceaglio, E. Zanini, F. Barpi, Issler, J?hannesson, M. Barbero, M. Borri-Brunetto, M. Freppaz, M. Maggioni, Maggioni, Margreth, O. Pallara, ROCSCIENCE Inc., Toronto (Canada), Sommavilla, Sommavilla, Thibert, Thibert, V. De Biagi   +26 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Placial Justice: Restoring Rehabilitation and Correctional Legitimacy Through Architectural Design

SAGE Open, 2020
Efforts to reduce the correction population have taken many forms across the United States, with the redesign of correctional edifices being met with mixed support from stakeholders.
Victor J. St. John
doaj   +1 more source

Satellite remote sensing facility for oceanograhic applications [PDF]

The project organization, design process, and construction of a Remote Sensing Facility at Scripps Institution of Oceanography at LaJolla, California are described.
Evans, R. H., Kent, S. S., Seidman, J. B.   +2 more
core   +1 more source

Design and Manufacture of the RF Power Supply and RF Transmission Line for SANAEM Project Prometheus

, 2017
A 1-5 MeV proton beamline is being built by the Turkish Atomic Energy Authority in collaboration with a number of graduate students from different universities.
Ahiska, F., Alacakir, A., Cicek, E., Kilic, I., Ogur, S., Ozbey, A., Turemen, G., Unel, G., Yasatekin, B.   +8 more
core   +1 more source