Results 71 to 80 of about 691,826 (352)

Rotating Band Pion Production Targets for Muon Colliders and Neutrino Factories [PDF]

, 2000
An update is presented on a conceptual design for a pion production target station using a rotating cupronickel band and that was originally proposed for use at a muon collider facility with a 4 MW pulsed proton beam.
King, B. J.
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Developing vanadium redox flow technology on a 9-kW 26-kWh industrial scale test facility: Design review and early experiments [PDF]

, 2018
Redox Flow Batteries (RFBs) have a strong potential for future stationary storage, in view of the rapid expansion of renewable energy sources and smart grids.
Alotto, Piergiorgio, D'Anzi, Angelo, Guarnieri, Massimo, TROVO', ANDREA   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Research on Public Facility Renewal Design System Under the Background of Future Community Construction [PDF]

, 2021
Rui Dong, Shen Yujia
openalex   +1 more source

Deep Underground Science and Engineering Laboratory - Preliminary Design Report

, 2011
The DUSEL Project has produced the Preliminary Design of the Deep Underground Science and Engineering Laboratory (DUSEL) at the rehabilitated former Homestake mine in South Dakota.
Acheson, Steven, Alonso, Jose, Bauer, Paul, Chan, Yuen-Dat, Chinowsky, William, Dangermond, Steve, De Vries, Syd, Detwiler, Jason A., DiGennaro, Richard, Exter, Elizabeth, Fernandez, Felix B., Freer, Elizabeth L., Gilchriese, Murdock G. D., Goldschmidt, Azriel, Grammann, Ben, Griffing, William, Harlan, Bill, Haxton, Wick C., Headley, Michael, Heise, Jaret, Hladysz, Zbigniew, Jacobs, Dianna, Johnson, Michael, Kadel, Richard, Kaufman, Robert, King, Greg, Lanou, Robert, Lemut, Alberto, Lesko, Kevin T., Ligeti, Zoltan, Marks, Steve, Martin, Ryan D., Matthesen, John, Matthew, Brendan, Matthews, Warren, McConnell, Randall, McElroy, William, Meyer, Deborah, Norris, Margaret, Plate, David, Robinson, Kem E., Roggenthen, William, Salve, Rohit, Sayler, Ben, Scheetz, John, Tarpinian, Jim, Taylor, David, Vardiman, David, Wheeler, Ron, Willhite, Joshua, Yeck, James   +50 more
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Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Application of importance-satisfaction analysis and influence-relations map to evaluate design delay factors

Journal of Civil Engineering and Management, 2014
Design delays can negatively influence the total completion time of a facility construction project. Knowing the factors to which design delays are most sensitive supports the time management of designs.
Wei-Chih Wang, Chia-Li Lin, Shih-Hsu Wang, Jang-Jeng Liu, Ming-Tsung Lee   +4 more
doaj   +1 more source

Materials and construction techniques for cryogenic wind tunnel facilities for instruction/research use [PDF]

The results of the cryogenic wind tunnel program conducted at NASA Langley Research Center are presented to provide a starting point for the design of an instructional/research wind tunnel facility.
Morse, S. F., Roper, A. T.
core   +1 more source

Prevention through design: Trade-offs in reducing occupational health and safety risk for the construction and operation of a facility [PDF]

, 2013
Purpose - The research aims to explore the interaction between design decisions that reduce occupational health and safety (OHS) risk in the operation stage of a facility's life cycle and the OHS experiences of workers in the construction stage ...
Blismas, N, Cooke, T, Lingard, H, Wakefield, R   +3 more
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