Results 91 to 100 of about 281,950 (300)

Level Control of Blast Furnace Gas Cleaning Tank System with Fuzzy Based Gain Regulation for Model Reference Adaptive Controller

open access: yes, 2022
Iron making processes and automation systems are mostly controlled by logical rules and PID controllers. The dynamic behavior of these processes varies due to factors such as raw materials, outdoor conditions, and equipment aging.
Aytaç Altan   +2 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Regulation 61-62.1 definitions and general requirements [PDF]

open access: yes, 2011
This regulation outlines the meanings of certain words and phrases used in the Regulations and Standards. It also emphasizes that it does not supersede any State or Federal requirements or special permit stipulations already in place.
South Carolina Department of Health and Environmental Control
core  

The Ayushman Bharat Digital Mission of India: An Assessment

open access: yesHealth Systems & Reform
India launched the Ayushman Bharat Digital Mission (ABDM) in 2021 to strengthen the digital health ecosystem by developing and integrating health data records and registries.
Udaya Shankar Mishra   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Experimental Demonstration of Frequency Regulation by Commercial Buildings—Part II: Results and Performance Evaluation [PDF]

open access: yes, 2017
This paper is the second part of a two-part series presenting the results from an experimental demonstration of frequency regulation in a commercial building test facility.
Vrettos, Evangelos   +4 more
core   +1 more source

The simulation model for a flood management by flood control facilities

open access: yesMATEC Web of Conferences, 2018
The rapid spread of storm floods over large areas requires flood management throughout the river basin by the creation an innovative system of flood control facilities of various functional purposes distributed in the area. The central part of the system
Davydov Roman   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

A Draft Design of a Zero-Power Experiment for Molten Salt Fast Reactor Studies

open access: yesEnergies
The UK government and many international experts have pointed out that nuclear energy has an important role to play in the transition towards a decarbonised energy system since it is the only freely manageable very low-carbon energy technology with 24/7 ...
Bruno Merk   +10 more
doaj   +1 more source

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