Results 81 to 90 of about 284,660 (296)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Evaluating different dimensions of programme effectiveness for private medicine retailer malaria control interventions in Kenya. [PDF]

, 2010
BACKGROUND: Private medicine retailers (PMRs) are key partners in the home management of fevers in many settings. Current evidence on effectiveness for PMR interventions at scale is limited.
Noor, Abdisalan M, Amin, AA, Snow, Robert, Willis S. Akhwale, Noor, AM, Willis S Akhwale, Akhwale, Willis S, Timothy O. Abuya, Abdinasir A. Amin, Greg Fegan, Akhwale, WS, Snow, Robert W, Amin, Abdinasir A, Abdinasir A Amin, Snow, RW, Robert W Snow, Fegan, G, Marsh, V, Abdisalan M Noor, Fegan, Greg, Robert W. Snow, Abuya, Timothy O, Abuya, TO, Marsh, Vicki, Timothy O Abuya, Abdisalan M. Noor, Vicki Marsh   +26 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Health facility surveys : an introduction [PDF]

Health facility surveys come in various guises. One dimension in which they vary is their motivation. Some seek to understand better links between households and providers. Others seek to understand better provider behavior and performance.
Lindelow, Magnus, Wagstaff, Adam
core  

Wireless Mid-Infrared Spectroscopy Sensor Network for Automatic Carbon Dioxide Fertilization in a Greenhouse Environment

Sensors, 2016
In this paper, a wireless mid-infrared spectroscopy sensor network was designed and implemented for carbon dioxide fertilization in a greenhouse environment.
Jianing Wang, Xintao Niu, Lingjiao Zheng, Chuantao Zheng, Yiding Wang   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Regulation 61-107.7 swm: transfer of solid waste [PDF]

, 1993
This regulation is to establish minimum standards for facilities where solid waste is transferred from collection vehicles to other transportation units for movement to another solid waste management facility prior to its processing and disposal.
South Carolina Department of Health and Environmental Control
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Re-evaluating the success of the EPA's 33/50 program: evidence from facility participation [PDF]

Using previously unavailable data, we examine facility participation in the 33/50 Program and its effect on aggregate and toxicity weighted emissions between1991 and 1995 for a sample of facilities whose parent firms committed to the Program. By focusing
Martina, Vidovic, Neha, Khanna
core  

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source