Results 81 to 90 of about 281,950 (300)

Limits to the (De-)Regulation of Transport Services [PDF]

In section 1 the disaggregated approach of network economics is explained which distinguishes between the network levels transport services, traffic control systems and fixed infrastructure.
Knieps, Günter
core  

Evaluating different dimensions of programme effectiveness for private medicine retailer malaria control interventions in Kenya. [PDF]

, 2010
BACKGROUND: Private medicine retailers (PMRs) are key partners in the home management of fevers in many settings. Current evidence on effectiveness for PMR interventions at scale is limited.
Noor, Abdisalan M, Amin, AA, Snow, Robert, Willis S. Akhwale, Noor, AM, Willis S Akhwale, Akhwale, Willis S, Timothy O. Abuya, Abdinasir A. Amin, Greg Fegan, Akhwale, WS, Snow, Robert W, Amin, Abdinasir A, Abdinasir A Amin, Snow, RW, Robert W Snow, Fegan, G, Marsh, V, Abdisalan M Noor, Fegan, Greg, Robert W. Snow, Abuya, Timothy O, Abuya, TO, Marsh, Vicki, Timothy O Abuya, Abdisalan M. Noor, Vicki Marsh   +26 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Regulation 61-107.6 swm: solid waste processing facilities [PDF]

, 1995
This regulation establishes the procedures, documentation, and other requirements which must be met for the proper operation and management of all solid waste processing facilities, including the processing activities involving the unrecoverable solid ...
South Carolina Department of Health and Environmental Control
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Tradeoffs in automated financial regulation of decentralized finance due to limits on mutable turing machines

Scientific Reports
We examine which decentralized finance architectures enable meaningful regulation by combining financial and computational theory. We show via deduction that a decentralized and permissionless Turing-complete system cannot provably comply with ...
Ben Charoenwong, Robert M. Kirby, Jonathan Reiter   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Health facility surveys : an introduction [PDF]

Health facility surveys come in various guises. One dimension in which they vary is their motivation. Some seek to understand better links between households and providers. Others seek to understand better provider behavior and performance.
Lindelow, Magnus, Wagstaff, Adam
core  

LEGAL REGULATION OF THE RESTORATION AND USE OF INTERNATIONAL FINANCIAL ASSISTANCE UNDER MARTIAL LAW IN UKRAINE

Baltic Journal of Economic Studies
This study examines the legal and institutional framework governing the attraction, distribution and control of international financial assistance in Ukraine under martial law.
Denys Manko, Olga Ivanchenko, Vira Ivanchuk   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source