Results 61 to 70 of about 284,660 (296)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Regulation number 61-109 standards for permitting body piercing facilities [PDF]
, 2002 The permit requirements for operating a body piercing facility in South Carolina are outlined in this regulation, which applies to individuals, organizations, political subdivisions, and governmental ...
South Carolina Department of Health and Environmental Control
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Regulation number 61-111 standards for licensing tattoo facilities [PDF]
, 2006 The license requirements for operating a tattoo facility in South Carolina are outlined in this regulation, which applies to individuals, organizations, political subdivisions, and governmental ...
South Carolina Department of Health and Environmental Control
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The Price and Complications of Safety Compliance – an Australian Perspective
Chemical Engineering Transactions, 2012 The high cost of major hazard facility (MHF) accidents, in terms of loss of lives, serious injuries, loss of production and associated cost of reputation and legal costs, require major hazard facilities to operate in a regulated regime designed to ...
C. Glavan, E. Palaneeswaran
doaj +1 more source
Identification of candidate genes associated with JA under elevated CO2 in carrot (Daucus carota L.)
Biotechnology & Biotechnological Equipment, 2021 CO2 application is one of the important ways to promote crop growth and increase yield, especially for facility crop cultivation. Since carrot is a widespread vegetable, the area of off-season facility cultivation has been increasing in recent years ...
Hongxia Song, Qiang Lu, Xiaoyu Guo
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
BMC Research Notes, 2019 Objective Indonesia ranks second globally in the number of cases not reported to the National Tuberculosis Control Program, accounting for 11% of the total cases lost worldwide.
Ari Kurniawati +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Regulation of an Open Access Essential Facility [PDF]
In this paper we consider the problem of regulating an open access essential facility. A vertically integrated firm owns an essential input and operates on the downstream market under the roof of a regulatory mechanism.
Manipushpak Mitra, Axel Gautier
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