Results 51 to 60 of about 284,660 (296)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Addressing the under-reporting of adverse drug reactions in public health programs controlling HIV/AIDS, Tuberculosis and Malaria: A prospective cohort study. [PDF]

PLoS ONE, 2018
BACKGROUND:Adverse Drug Reactions (ADRs) are a major clinical and public health problem world-wide. The prompt reporting of suspected ADRs to regulatory authorities to activate drug safety surveillance and regulation appears to be the most pragmatic ...
Yohanna Kambai Avong, Bolajoko Jatau, Ritmwa Gurumnaan, Nanfwang Danat, James Okuma, Istifanus Usman, Dennis Mordi, Blessing Ukpabi, Gbenga Ayodele Kayode, Saswata Dutt, Osman El-Tayeb, Bamgboye Afolabi, Isah Ambrose, Oche Agbaji, Adeline Osakwe, Ali Ibrahim, Comfort Ogar, Helga Nosiri, Eunice B Avong, Victor Adekanmbi, Olalekan Uthman, Alash'le Abimiku, Yetunde O Oni, Charles Olalekan Mensah, Patrick Dakum, Kamau Edward Mberu, Olumide A T Ogundahunsi   +26 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Regulation 61-13 standards for licensing intermediate care facilities for individuals with intellectual disabilities [PDF]

, 2021
This regulation establishes comprehensive requirements and standards for habilitation centers catering to individuals with intellectual disabilities or related conditions, with a strong emphasis on ensuring compliance, prioritizing safety, and promoting ...
South Carolina Department of Health and Environmental Control
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Recent Progress of Phase Change Materials and Their Applications in Facility Agriculture and Related-Buildings—A Review

Buildings
Facility agriculture, which involves agricultural production in controlled environments such as greenhouses, indoor farms, and vertical farms, aims to maximize efficiency, yield, and quality while minimizing resource consumption and environmental impact.
Yijing Cui, Raza Gulfam, Yousaf Ishrat, Saqib Iqbal, Feng Yao   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Technical Measures to Mitigate Load Fluctuation for Large-Scale Customers to Improve Power System Energy Efficiency

Energies, 2020
Industrial equipment such as electric arc furnaces and steel mills are often associated with rapid and high load disturbances, so their power systems require additional control equipment to limit the frequency.
Yongsik Lee, Hyunchul Lee, Jaehyeon Gim, Inyong Seo, Guenjoon Lee   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source