Results 51 to 60 of about 281,950 (300)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Technical Measures to Mitigate Load Fluctuation for Large-Scale Customers to Improve Power System Energy Efficiency

Energies, 2020
Industrial equipment such as electric arc furnaces and steel mills are often associated with rapid and high load disturbances, so their power systems require additional control equipment to limit the frequency.
Yongsik Lee, Hyunchul Lee, Jaehyeon Gim, Inyong Seo, Guenjoon Lee   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Recent Progress of Phase Change Materials and Their Applications in Facility Agriculture and Related-Buildings—A Review

Buildings
Facility agriculture, which involves agricultural production in controlled environments such as greenhouses, indoor farms, and vertical farms, aims to maximize efficiency, yield, and quality while minimizing resource consumption and environmental impact.
Yijing Cui, Raza Gulfam, Yousaf Ishrat, Saqib Iqbal, Feng Yao   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

An automated boron management system for WWER-1000 nuclear reactors

Trudy Odesskogo Politehničeskogo Universiteta, 2014
The article is devoted to the problem of creating a system of automated control with boron regulation for reactor WWER-1000 series. Using the boron regulation to control WWER-1000 allows to extend its maximum output operation period, ensuring the ...
Таїсія Олександрівна Цисельська, Андрій В. Ковтун   +1 more
doaj  

Identification of candidate genes associated with JA under elevated CO2 in carrot (Daucus carota L.)

Biotechnology & Biotechnological Equipment, 2021
CO2 application is one of the important ways to promote crop growth and increase yield, especially for facility crop cultivation. Since carrot is a widespread vegetable, the area of off-season facility cultivation has been increasing in recent years ...
Hongxia Song, Qiang Lu, Xiaoyu Guo
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Price and Complications of Safety Compliance – an Australian Perspective

Chemical Engineering Transactions, 2012
The high cost of major hazard facility (MHF) accidents, in terms of loss of lives, serious injuries, loss of production and associated cost of reputation and legal costs, require major hazard facilities to operate in a regulated regime designed to ...
C. Glavan, E. Palaneeswaran
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source