Results 51 to 60 of about 811,714 (302)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Acceptability of mandatory tuberculosis notification among private practitioners in Yogyakarta, Indonesia

BMC Research Notes, 2019
Objective Indonesia ranks second globally in the number of cases not reported to the National Tuberculosis Control Program, accounting for 11% of the total cases lost worldwide.
Ari Kurniawati, Retna S. Padmawati, Yodi Mahendradhata   +2 more
doaj   +1 more source

Stereoscopic Light Environment Intelligent Control System Based on Characteristic Differences of Facility Cucumber Plants Light Requirements

智慧农业, 2020
Light is the main energy source for plants to carry out photosynthesis, and the quality of light directly affects the yield and quality of crops. In view of the fact that most of the existing plant light supplement systems are based on the photosynthetic
ZHANG Zhongxiong, LI Bin, FENG Pan, ZHANG Pan, LAI Haibin, HU Jin, ZHANG Haihui   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Municipal Solid Waste Flow Control in the Post-Carbone World [PDF]

, 1995
Garbage will always ultimately be the government\u27s problem. Evolving environmental standards and state and federal policies will continue to require reasoned responses from local governments and municipal solid waste flow control is a vital cog in ...
Abramowitz, David N., Peterson, Eric S.
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Perbedaan Harga Lahan Sebagai Akibat Terjadinya Fenomena Percampuran Ruang Bermukim di Wilayah Pinggiran Kota Semarang (Studi Kasus Perumahan Formal dan Informal di Kelurahan Pedalangan & Bulusan)

Jurnal Wilayah dan Lingkungan, 2013
Suburbanization is  a  process  to  shape  built  areas  as  an  impact  urban development  expansion (Wiratmaja, 2002:33). The real form of suburbanization is shift settlements activity towards suburban area.
Wily Alfi Gustiana
doaj   +1 more source

Effluent limits, ambient quality, and monitoring [PDF]

, 2013
Effluent limits are frequently based on a uniform emission standard, which applies to all polluting facilities within in a single industry. However, the implementation of many environmental protection laws does not lead to uniform effluent limits due ...
Arguedas, Carmen, Earnhart, Dietrich, Rousseau, Sandra   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source