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Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1
The Journal of Immunology, 1995Abstract The human factor H-like protein 1 (FHL-1) is composed of seven repetitive domains (short consensus repeats; SCRs) that are identical in sequence to the seven NH2-terminal SCRs of the complement regulatory protein factor H. We have identified the native FHL-1 protein as a 42-kDa human plasma protein by immunoblotting and by ...
S, Kühn, C, Skerka, P F, Zipfel
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The Journal of Immunology, 1998
Abstract The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds to group A streptococci and that the interaction does not interfere with the complement-inhibitory capacity of FH. In this work, we report a molecular analysis of this interaction.
H, Kotarsky +7 more
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Abstract The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds to group A streptococci and that the interaction does not interfere with the complement-inhibitory capacity of FH. In this work, we report a molecular analysis of this interaction.
H, Kotarsky +7 more
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European Journal of Immunology, 1996
AbstractThe human factor H‐like protein 1 (FHL‐1) is composed of seven repetitive elements (short consensus repeats; SCR) that are identical in sequence to the seven N‐terminal SCR of complement factor H. We show that the FHL‐1 protein has decay acceleration activity in that it can dissociate C3/C5‐convertases bound to the surface of sheep red blood ...
S, Kühn, P F, Zipfel
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AbstractThe human factor H‐like protein 1 (FHL‐1) is composed of seven repetitive elements (short consensus repeats; SCR) that are identical in sequence to the seven N‐terminal SCR of complement factor H. We show that the FHL‐1 protein has decay acceleration activity in that it can dissociate C3/C5‐convertases bound to the surface of sheep red blood ...
S, Kühn, P F, Zipfel
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Molecular Microbiology, 2001
Factor H (FH) and factor H‐like protein 1 (FHL‐1) regulate complement activation through the alternative pathway. Several extracellular bacterial pathogens, prime targets for the complement system, bind FH and FHL‐1, thereby acquiring a potential mechanism for minimizing complement deposition on their surface.
H, Kotarsky +5 more
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Factor H (FH) and factor H‐like protein 1 (FHL‐1) regulate complement activation through the alternative pathway. Several extracellular bacterial pathogens, prime targets for the complement system, bind FH and FHL‐1, thereby acquiring a potential mechanism for minimizing complement deposition on their surface.
H, Kotarsky +5 more
openaire +2 more sources
A Prion-Like Protein Regulator of Seed Germination Undergoes Hydration-Dependent Phase Separation
Cell, 2021Moises Exposito-Alonso +2 more
exaly