Results 91 to 100 of about 36,099,759 (329)

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.

Journal of the American Society of Nephrology, 2013
Factor H (fH) and properdin both modulate complement; however, fH inhibits activation, and properdin promotes activation of the alternative pathway of complement.
Allison M. Lesher, Lin Zhou, Yuko Kimura, Sayaka Sato, Damodar Gullipalli, A. Herbert, P. Barlow, H. Eberhardt, C. Skerka, P. Zipfel, T. Hamano, T. Miwa, K. Tung, W. Song   +13 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency.

Journal of the American Society of Nephrology, 2013
Complement factor H (CFH) is a negative regulator of the alternative pathway of complement, and properdin is the sole positive regulator. CFH-deficient mice (CFH(-/-)) develop uncontrolled C3 activation and spontaneous renal disease characterized by ...
M. Ruseva, K. Vernon, Allison M. Lesher, W. Schwaeble, Youssif M. Ali, M. Botto, T. Cook, W. Song, C. Stover, M. Pickering   +9 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Vortex states in superconductors with strong Pauli-paramagnetic effect

, 2007
Using the quasiclassical theory, we analyze the vortex structure of strong-paramagnetic superconductors.There, induced paramagnetic moments are accumulated exclusively around the vortex core. We quantitatively evaluate the significant paramagnetic effect
A. I. Larkin, A. P. Ramirez, G. E. Volovik, Kazushige Machida, Masanori Ichioka   +4 more
core   +1 more source

Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology

Nefrología (English Edition), 2022
The complement system is a first line of defence against infectious, tumoral or autoimmune processes, and it is constitutively regulated to avoid excessive or unspecific activation. Factor H (FH), a most relevant complement regulator, controls complement
Irene Gómez Delgado, Pilar Sánchez-Corral   +1 more
doaj  

Scientific journals in the SciELO database, indicators of impact and the relative position of Ambiente & Água

Revista Ambiente & Água, 2010
This editorial describes the process of periodic evaluation by CAPES, based on commercial indices proposed by companies such as the ISI FI by Thomson Reuters and SCImago by Scopus and public indices as proposed by SciELO and other freely calculated ...
Nelson Wellausen Dias, Getulio Teixeira Batista   +1 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.

Journal of Infectious Diseases, 2013
Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal complement-evasion molecules, C.
Shanshan Luo, R. Hoffmann, C. Skerka, P. Zipfel   +3 more
semanticscholar   +1 more source

Discussion: “Measurement of Recovery Factors and Friction Coefficients for Supersonic Flow of Air in a Tube: Part 1—Apparatus Data and Results Based on a Simple One-Dimensional Flow Model” (Kaye, J., Keenan, J. H., Klingensmith, K. K., Ketchum, G. M., and Toong, T. Y., 1952, ASME J. Appl. Mech., 19, pp. 77–96) [PDF]

, 1953
Richard Scherrer
openalex   +3 more sources