Results 91 to 100 of about 28,482,475 (369)

Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein

open access: yesmSphere, 2019
Meningococcal serogroup B (MenB) vaccines contain recombinant factor H binding protein (FHbp), which can complex with complement factor H (CFH) and thereby risk eliciting anti-FH autoantibodies.
Kelsey Sharkey   +8 more
doaj   +1 more source

Complement-Independent Modulation of Influenza A Virus Infection by Factor H

open access: yesFrontiers in Immunology, 2020
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface ...
Valarmathy Murugaiah   +11 more
doaj   +1 more source

Recognizing $\mathrm{PSL}(2,p)$ in the non-Frattini chief factors of finite groups [PDF]

open access: yesarXiv, 2015
Given a finite group $G$, let $P_G(s)$ be the probability that $s$ randomly chosen elements generate $G$, and let $H$ be a finite group with $P_G(s)=P_H(s)$. We show that if the nonabelian composition factors of $G$ and $H$ are $\mathrm{PSL}(2,p)$ for some non-Mersense prime $p\geq 5$, then $G$ and $H$ have the same non-Frattini chief factors.
arxiv  

Factor H complements AMD [PDF]

open access: yesScience-Business eXchange, 2011
EU and U.S. researchers have revealed what could be the mechanistic underpinnings of the increased risk for age-related macular degeneration in individuals with a common polymorphism in the gene for complement factor H.
openaire   +2 more sources

On factor width and symmetric H-matrices [PDF]

open access: yesLinear Algebra and its Applications, 2005
AbstractWe define a matrix concept we call factor width. This gives a hierarchy of matrix classes for symmetric positive semidefinite matrices, or a set of nested cones. We prove that the set of symmetric matrices with factor width at most two is exactly the class of (possibly singular) symmetric H-matrices (also known as generalized diagonally ...
Doron Chen   +3 more
openaire   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Dominant tournament families [PDF]

open access: yesarXiv, 2020
For a tournament $H$ with $h$ vertices, its typical density is $h!2^{-\binom{h}{2}}/aut(H)$, i.e. this is the expected density of $H$ in a random tournament. A family ${\mathcal F}$ of $h$-vertex tournaments is {\em dominant} if for all sufficiently large $n$, there exists an $n$-vertex tournament $G$ such that the density of each element of ${\mathcal
arxiv  

Human Factor H-Related Protein 2 (CFHR2) Regulates Complement Activation

open access: yesPLoS ONE, 2013
Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
H. Eberhardt   +10 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

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