The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury [PDF]
, 2023 Chia Wei Teoh +10 more
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, 2012 Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR). The complement factor H gene (CFH) is located on chromosome 1q32 in the regulators of complement activation (RCA) gene cluster, adjacent to the genes that code ...
Dinasarapu, Ashok Reddy +3 more
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Frontiers in Immunology, 2018 Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor ...
Richard B. Pouw +8 more
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Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement
Frontiers in ImmunologyChagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon +6 more
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Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS
Frontiers in Immunology, 2019 Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and renal failure. It is caused by genetic or acquired defects of the complement alternative pathway. Factor H autoantibodies
Elisabetta Valoti +14 more
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Recognition of Malondialdehyde-modified Proteins by the C Terminus of Complement Factor H Is Mediated via the Polyanion Binding Site and Impaired by Mutations Found in Atypical Hemolytic Uremic Syndrome [PDF]
, 2013 Satu Hyvärinen +4 more
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Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H [PDF]
, 1984 Jochem Alsenz +3 more
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Investigating the [C ii]-to-H i Conversion Factor and the H i Gas Budget of Galaxies at z ≈ 6 with Hydrodynamic Simulations [PDF]
, 2022 David Vizgan +7 more
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Editorial: Function and Dysfunction of Complement Factor H
Frontiers in Immunology, 2022 Mihály Józsi +2 more
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Atypical hemolytic uremic syndrome due to factor H autoantibody
The Turkish Journal of Pediatrics, 2013 Atypical hemolytic uremic syndrome (aHUS) is a disease caused by pathologies in the alternative complement system. The prevalence of aHUS is 10% of all aHUS cases.
Arife Uslu-Gökceoğlu +4 more
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