Results 101 to 110 of about 36,394,742 (371)

Human Factor H-Related Protein 2 (CFHR2) Regulates Complement Activation

PLoS ONE, 2013
Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
H. Eberhardt, D. Buhlmann, P. Hortschansky, Qiang Chen, S. Böhm, M. Kemper, R. Wallich, A. Hartmann, T. Hallström, P. Zipfel, C. Skerka   +10 more
semanticscholar   +1 more source

Short-time height distribution in 1d KPZ equation: starting from a parabola

, 2016
We study the probability distribution $\mathcal{P}(H,t,L)$ of the surface height $h(x=0,t)=H$ in the Kardar-Parisi-Zhang (KPZ) equation in $1+1$ dimension when starting from a parabolic interface, $h(x,t=0)=x^2/L$. The limits of $L\to\infty$ and $L\to 0$
Kamenev, Alex, Meerson, Baruch, Sasorov, Pavel V.   +2 more
core   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.

Journal of the American Society of Nephrology, 2013
Factor H (fH) and properdin both modulate complement; however, fH inhibits activation, and properdin promotes activation of the alternative pathway of complement.
Allison M. Lesher, Lin Zhou, Yuko Kimura, Sayaka Sato, Damodar Gullipalli, A. Herbert, P. Barlow, H. Eberhardt, C. Skerka, P. Zipfel, T. Hamano, T. Miwa, K. Tung, W. Song   +13 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Factor H complements AMD [PDF]

Science-Business eXchange, 2011
EU and U.S. researchers have revealed what could be the mechanistic underpinnings of the increased risk for age-related macular degeneration in individuals with a common polymorphism in the gene for complement factor H.
openaire   +2 more sources

$D^*D\pi$ and $B^*B\pi$ form factors from QCD Sum Rules

, 2000
The $H^*H\pi$ form factor for H = B and D mesons is evaluated in a QCD sum rule calculation. We study the Borel sum rule for the three point function of two pseudoscalar and one vector meson currents up to order four in the operator product expansion ...
Ball, Becirevic, Belyaev, Bracco, C.L Schat, Casalbuoni, Colangelo, Colangelo, Cutkosky, Dosch, F.S Navarra, Grozin, Ioffe, Khodjamirian, M Chiapparini, M Nielsen, M.E Bracco, Matinyan, Matsui, Navarra, Reinders, Singer   +21 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.

Journal of Infectious Diseases, 2013
Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal complement-evasion molecules, C.
Shanshan Luo, R. Hoffmann, C. Skerka, P. Zipfel   +3 more
semanticscholar   +1 more source

An Ore-type theorem for perfect packings in graphs

, 2009
We say that a graph G has a perfect H-packing (also called an H-factor) if there exists a set of disjoint copies of H in G which together cover all the vertices of G.
Kühn, Daniela, Osthus, Deryk, Treglown, Andrew   +2 more
core   +2 more sources