Results 101 to 110 of about 28,482,475 (369)
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.
Journal of the American Society of Nephrology, 2013 Factor H (fH) and properdin both modulate complement; however, fH inhibits activation, and properdin promotes activation of the alternative pathway of complement.
Allison M. Lesher +13 more
semanticscholar +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Toward a Dichotomy for Approximation of $H$-coloring [PDF]
arXiv, 2019 Given two (di)graphs G, H and a cost function $c:V(G)\times V(H) \to \mathbb{Q}_{\geq 0}\cup\{+\infty\}$, in the minimum cost homomorphism problem, MinHOM(H), goal is finding a homomorphism $f:V(G)\to V(H)$ (a.k.a H-coloring) that minimizes $\sum\limits_{v\in V(G)}c(v,f(v))$. The complexity of exact minimization of this problem is well understood [34],
arxiv
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Nefrología (English Edition), 2022 The complement system is a first line of defence against infectious, tumoral or autoimmune processes, and it is constitutively regulated to avoid excessive or unspecific activation. Factor H (FH), a most relevant complement regulator, controls complement
Irene Gómez Delgado +1 more
doaj
Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”
Frontiers in Immunology, 2013 Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by ...
Lubna Kouser +5 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Journal of Infectious Diseases, 2013 Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal complement-evasion molecules, C.
Shanshan Luo +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Revista Ambiente & Água, 2010 This editorial describes the process of periodic evaluation by CAPES, based on commercial indices proposed by companies such as the ISI FI by Thomson Reuters and SCImago by Scopus and public indices as proposed by SciELO and other freely calculated ...
Nelson Wellausen Dias +1 more
doaj +1 more source