Results 121 to 130 of about 28,482,475 (369)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

On solvable factors of almost simple groups [PDF]

open access: yesarXiv, 2019
Let $G$ be a finite almost simple group with socle $G_0$. A (nontrivial) factorization of $G$ is an expression of the form $G=HK$, where the factors $H$ and $K$ are core-free subgroups. There is an extensive literature on factorizations of almost simple groups, with important applications in permutation group theory and algebraic graph theory.
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini   +11 more
wiley   +1 more source

Bounds on treewidth via excluding disjoint unions of cycles [PDF]

open access: yesarXiv
One of the fundamental results in graph minor theory is that for every planar graph~$H$, there is a minimum integer~$f(H)$ such that graphs with no minor isomorphic to~$H$ have treewidth at most~$f(H)$. The best known bound for an arbitrary planar $H$ is ${O(|V(H)|^9\operatorname{poly~log} |V(H)|)}$. We show that if $H$ is the disjoint union of cycles,
arxiv  

A note on absolute summability factors [PDF]

open access: yesProc. Indian Acad. Sci. (Math. Sci.), Vol. 113, No. 2, May 2003, pp. 165-169, 2003
In this paper, by using an almost increasing and $\delta$-quasi-monotone sequence, a general theorem on $\phi-{\mid{C},\alpha\mid}_k$ summability factors, which generalizes a result of Bor \cite{3} on ${\phi-\mid{C},1\mid}_k$ summability factors, has been proved under weaker and more general conditions.
arxiv  

Stable LU factorization of H-matrices

open access: yesLinear Algebra and its Applications, 1988
AbstractResults are given concerning the LU factorization of H-matrices, and Gaussian elimination with column-diagonal-dominant pivoting is shown to be applicable to H-matrices. This algorithm, which uses a symmetric permutation to exchange the most diagonally dominant column of the unreduced submatrix into the pivotal position, is shown to be ...
Dale D. Olesky   +2 more
openaire   +2 more sources

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2012
The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD).
Peter Shaw   +30 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B

open access: yesFrontiers in Immunology, 2018
Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor ...
Richard B. Pouw   +8 more
doaj   +1 more source

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