Results 141 to 150 of about 28,482,475 (369)

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

On the arithmetic of power monoids [PDF]

open access: yesarXiv
Given a monoid $H$ (written multiplicatively), the family $\mathcal P_{{\rm fin},1}(H)$ of all non-empty finite subsets of $H$ that contain the identity $1_H$ is itself a monoid (called the reduced finitary power monoid of $H$) when equipped with the operation of setwise multiplication induced by $H$.
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

A fast computation of density of exponentially $S$-numbers [PDF]

open access: yesarXiv, 2016
The author \cite{4} proved that, for every set $S$ of positive integers containing 1 (finite or infinite) there exists the density $h=h(E(S))$ of the set $E(S)$ of numbers whose prime factorizations contain exponents only from $S,$ and gave an explicit formula for $h(E(S)).$ In this paper we give an equivalent polynomial formula for $\log h(E(S ...
arxiv  

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Atypical hemolytic uremic syndrome due to factor H autoantibody

open access: yesThe Turkish Journal of Pediatrics, 2013
Atypical hemolytic uremic syndrome (aHUS) is a disease caused by pathologies in the alternative complement system. The prevalence of aHUS is 10% of all aHUS cases.
Arife Uslu-Gökceoğlu   +4 more
doaj  

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