Results 161 to 170 of about 3,730,271 (242)

Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice. [PDF]

Cell Mol Neurobiol
Naskar A, Sachin M, Sengupta S, Bhadrachalam P, Hegde S, Yadav R, Pal PK, Alladi PA.   +7 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Factor H-related 2 levels dictate FHR dimer composition. [PDF]

Sci Rep
Veuskens BRJ, Brouwer MC, van Mierlo G, Geissler J, van Leeuwen K, Derlagen M, Keijzer NCH, Hoogenboezem M, Kuijpers TW, Pouw RB.   +9 more
europepmc   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Disease Progression in Age-Related Macular Degeneration Patients Carrying Rare Variants in the Complement Factor H or Complement Factor I Genes. [PDF]

Invest Ophthalmol Vis Sci
Cinque F, de Breuk A, Mhmud H, De Jong S, Vermeulen J, Liefers B, den Hollander AI, Thee E, Colijn JM, Heesterbeek TJ, Klaver CC, Hoyng CB, Lechanteur YTE.   +12 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy. [PDF]

Front Immunol
Slagle AK, Ghiringhelli Borsa N, Wang K, Taylor AO, Meyer NC, Jones MB, Walls WD, Nelson AFM, Roberts SM, Sun M, Goicoechea de Jorge E, Rodriguez de Cordoba S, Jalal DI, Nester CM, Zhang Y, Smith RJH.   +15 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration. [PDF]

J Neuroinflammation
Sekulic A, Herr SM, Mulfaul K, Pompös IM, Winkler S, Dietrich C, Obermayer B, Mullins RF, Conrad T, Zipfel PF, Sennlaub F, Skerka C, Strauß O.   +12 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source