Results 161 to 170 of about 3,567,577 (243)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Complement Factor H Y403H Polymorphism in the Turkish Population

Balkan Journal of Medical Genetics, 2010
Yunus Arikan, Türker Bilgen, Ibrahim Keser   +2 more
doaj   +1 more source

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H. [PDF]

Invest Ophthalmol Vis Sci
Swan J, Toomey CB, Bergstrand M, Cuello HA, Robie J, Yu H, Yuan Y, Kooner AS, Chen X, Shaughnessy J, Ram S, Varki A, Gagneux P.   +12 more
europepmc   +1 more source

Study of Correlation between H. pylori, Life Habits, and Risk Factors among Adult Patients in Gharyan, Libya

Najia Mahdawi, Ibrahim Karim, Najat Alaswad   +2 more
openalex   +2 more sources

Factor H Binding to PspC ofStreptococcus pneumoniaeIncreases Adherence to Human Cell Lines In Vitro and Enhances Invasion of Mouse Lungs In Vivo

, 2007
Lisa R. Quin, Chinwendu Onwubiko, Quincy C. Moore, Megumi F. Mills, Larry S. McDaniel, Stephanie Carmicle   +5 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Glycoproteomics analysis of complement factor H and its complement-regulatory function during <i>Streptococcus pneumoniae</i>-associated hemolytic uremic syndrome. [PDF]

Front Immunol
Baas LM, Wijnsma KL, Zijlstra F, van de Kar NCAJ, Ter Steeg L, Bouts AHM, Michels MAHM, Langereis JD, Lefeber D, Wessels HJCT, van den Heuvel LP.   +10 more
europepmc   +1 more source

Synergy of Putative Binding Modes in the Factor H (CCP 19-20) and C3d Complex [PDF]

, 2016
R Harrison, Ronald D. Gorham, Dimitrios Morikis   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment. [PDF]

Cancer Immunol Res
Smolag KI, Olszowka J, Rosberg R, Johansson E, Marinko E, Leandersson K, O'Connell DJ, Governa V, Tuysuz EC, Belting M, Pietras A, Martin M, Blom AM.   +12 more
europepmc   +1 more source