Results 191 to 200 of about 11,953,655 (218)

Human complement factor H

, 1991
Schwaeble, W., Feifel, E., Estaller, C., Barbieri, A., Molgg, M., Koistinen, V., Weiss, Elisabeth H., Dierich, Manfred P.   +7 more
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Factors governing the design, selection and cleavage of sugar-modified duplexes by ribonuclease H

, 2005
Maria Mangos
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Factor H

1990
While the mouse and human H proteins are structurally and functionally similar, they differ in their genetics. Whereas there is no evidence in humans for more than one gene; in mice the H locus is complex. Based on cDNA sequence and hybridization analysis of genomic cosmid clones, there are at least three distinct genes, all highly related to one ...
D P, Vik, P, Muñoz-Cánoves, D D, Chaplin, B F, Tack   +3 more
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Factor H-Related Proteins

2013
Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Józsi, Mihály, Meri, Seppo
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The factor H protein family

Immunopharmacology, 1999
The factor H gene family provides a prime example of a multidomain multifunctional protein family whose individual members are defined by conserved common structural elements and display diverse but often overlapping functions. The six identified members of this protein family represent secreted plasma proteins that are primarily synthesized in the ...
P F, Zipfel, T S, Jokiranta, J, Hellwage, V, Koistinen, S, Meri   +4 more
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Anti-Factor H Autoantibodies Assay

2013
Non-Shiga-toxin-associated hemolytic uremic syndrome (atypical HUS) is a rare form of thrombotic microangiopathy which associates hemolytic anemia, thrombocytopenia, and acute renal failure. In 10 % of cases the disease is linked to presence of autoantibodies directed against Factor H (FH), the main plasmatic alternative complement pathway regulatory ...
Marie-Agnès, Dragon-Durey, Caroline, Blanc, Lubka T, Roumenina, Nelly, Poulain, Stéphanie, Ngo, Pauline, Bordereau, Véronique, Frémeaux-Bacchi   +6 more
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Threshold Functions for H-factors

Combinatorics, Probability and Computing, 1993
Let H be a graph on h vertices, and G be a graph on n vertices. An H-factor of G is a spanning subgraph of G consisting of n/h vertex disjoint copies of H. The fractional arboricity of H is , where the maximum is taken over all subgraphs (V′, E′) of H with |V′| > 1. Let δ(H) denote the minimum degree of a vertex of H. It is shown that if δ(H) < a(
Alon, Noga, Yuster, Raphael
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Functional Anatomy of Complement Factor H

Biochemistry, 2013
Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief role is to prevent complement-mediated injury to healthy host cells and tissues. This entails recognition
Elisavet, Makou, Andrew P, Herbert, Paul N, Barlow   +2 more
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Anti-complement-factor H-associated glomerulopathies

Nature Reviews Nephrology, 2016
Atypical haemolytic uraemic syndrome (aHUS), an important cause of acute kidney injury, is characterized by dysregulation of the complement pathway, frequent need for dialysis, and progression to end-stage renal disease. Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement ...
Marie-Agnes Dragon, Durey, Aditi, Sinha, Shambhuprasad Kotresh, Togarsimalemath, Arvind, Bagga   +3 more
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