Results 291 to 300 of about 11,250,106 (333)
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1990
While the mouse and human H proteins are structurally and functionally similar, they differ in their genetics. Whereas there is no evidence in humans for more than one gene; in mice the H locus is complex. Based on cDNA sequence and hybridization analysis of genomic cosmid clones, there are at least three distinct genes, all highly related to one ...
D P, Vik +3 more
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While the mouse and human H proteins are structurally and functionally similar, they differ in their genetics. Whereas there is no evidence in humans for more than one gene; in mice the H locus is complex. Based on cDNA sequence and hybridization analysis of genomic cosmid clones, there are at least three distinct genes, all highly related to one ...
D P, Vik +3 more
openaire +2 more sources
Immunopharmacology, 1999
The factor H gene family provides a prime example of a multidomain multifunctional protein family whose individual members are defined by conserved common structural elements and display diverse but often overlapping functions. The six identified members of this protein family represent secreted plasma proteins that are primarily synthesized in the ...
Vesa Koistinen +4 more
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The factor H gene family provides a prime example of a multidomain multifunctional protein family whose individual members are defined by conserved common structural elements and display diverse but often overlapping functions. The six identified members of this protein family represent secreted plasma proteins that are primarily synthesized in the ...
Vesa Koistinen +4 more
openaire +3 more sources
2013
Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Mihály Józsi +2 more
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Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Mihály Józsi +2 more
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Functional Anatomy of Complement Factor H
Biochemistry, 2013Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief role is to prevent complement-mediated injury to healthy host cells and tissues. This entails recognition
Paul N. Barlow +2 more
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The form factor of H-comb polymers
The Journal of Chemical Physics, 2009A Monte Carlo pivot algorithm is employed to investigate the form factor of continuum, tangent hard sphere H-comb polymers in both the ideal and excluded volume regimes. The simulated form factors for 241 and 931 “bead” ideal H-combs are essentially the same.
Steven Zweier, Marvin Bishop
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British Journal of Healthcare Assistants, 2012
This article describes some of the concepts associated with taking a human factors approach to patient safety in healthcare. It has been designed to help healthcare support workers understand the ways in which they interact with systems at work and how poorly-designed, flawed systems can have a potentially detrimental impact on their performance at ...
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This article describes some of the concepts associated with taking a human factors approach to patient safety in healthcare. It has been designed to help healthcare support workers understand the ways in which they interact with systems at work and how poorly-designed, flawed systems can have a potentially detrimental impact on their performance at ...
openaire +2 more sources
Anti-Factor H Autoantibodies Assay
2013Non-Shiga-toxin-associated hemolytic uremic syndrome (atypical HUS) is a rare form of thrombotic microangiopathy which associates hemolytic anemia, thrombocytopenia, and acute renal failure. In 10 % of cases the disease is linked to presence of autoantibodies directed against Factor H (FH), the main plasmatic alternative complement pathway regulatory ...
Véronique Frémeaux-Bacchi +7 more
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The Pleiotropy of Complement Factor H
JAMA Ophthalmology, 2023Elizabeth J, Rossin, Lucia, Sobrin
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Factor H and the pathogenesis of renal diseases
Pediatric Nephrology, 2000Complement factor H is a potent inhibitor of alternative pathway complement activation. The factor H gene, a member of the regulators of complement activation (RCA) gene cluster, encodes two plasma proteins, one 150 kilodaltons (kDa) and one 43 kDa.
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