Results 81 to 90 of about 28,482,475 (369)

Dimerization of complement factor H-related proteins modulates complement activation in vivo

Proceedings of the National Academy of Sciences of the United States of America, 2013
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus.
E. Goicoechea de Jorge, Joseph J. E. Caesar, T. Malik, Mitali M. Patel, Matthew Colledge, Steven Johnson, S. Hakobyan, B. Morgan, C. Harris, M. Pickering, S. Lea   +10 more
semanticscholar   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Defining the binding region in factor H to develop a therapeutic factor H-Fc fusion protein against nontypeable Haemophilus influenzae

Frontiers in Cellular and Infection Microbiology, 2016
Nontypeable Haemophilus influenzae (NTHi) cause a range of illnesses including otitis media, sinusitis, and exacerbation of chronic obstructive pulmonary disease, infections that contribute to the problem of antibiotic resistance and are themselves often
Sandy M. Wong, Jutamas eShaughnessy, Sanjay eRam, Brian J. Akerley   +3 more
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Ramsey goodness of bounded degree trees [PDF]

arXiv, 2016
Given a pair of graphs $G$ and $H$, the Ramsey number $R(G,H)$ is the smallest $N$ such that every red-blue coloring of the edges of the complete graph $K_N$ contains a red copy of $G$ or a blue copy of $H$. If a graph $G$ is connected, it is well known and easy to show that $R(G,H) \geq (|G|-1)(\chi(H)-1)+\sigma(H)$, where $\chi(H)$ is the chromatic ...
arxiv  

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

Proceedings of the National Academy of Sciences of the United States of America, 2013
Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for understanding the nature of immune responses and designing improved vaccines, therapeutics, and diagnostics.
E. Malito, A. Faleri, P. Lo Surdo, D. Veggi, Giulietta Maruggi, E. Grassi, E. Cartocci, Isabella Bertoldi, A. Genovese, L. Santini, G. Romagnoli, E. Borgogni, S. Brier, C. Lo Passo, M. Domina, F. Castellino, F. Felici, S. van der Veen, Steven Johnson, S. Lea, C. Tang, M. Pizza, S. Savino, N. Norais, R. Rappuoli, M. Bottomley, V. Masignani   +26 more
semanticscholar   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Affine factorable surfaces in isotropic spaces [PDF]

arXiv, 2018
In this paper, we study the problem of finding the affine factorable surfaces in a 3-dimensional isotropic space with prescribed Gaussian (K) and mean (H) curvature. Because the absolute figure two different types of these surfaces appear by permutation of coordinates.
arxiv  

Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome.

American Society of Nephrology. Clinical Journal, 2013
BACKGROUND AND OBJECTIVES This study evaluated the relevance of complement factor H (CFH)-related protein (CFHR) 1 deficiency in pediatric patients with atypical hemolytic uremic syndrome (aHUS) by evaluating both the frequency of deletions in CFHR1 and ...
J. Hofer, A. Janecke, L. Zimmerhackl, M. Riedl, A. Rosales, T. Giner, G. Cortina, Carola J Haindl, Barbara Petzelberger, M. Pawlik, V. Jeller, U. Vester, B. Gadner, M. Husen, M. Moritz, R. Würzner, T. Jungraithmayr   +16 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source