Results 121 to 130 of about 12,704,954 (241)

Clinical case of cutaneous vasculopathy due to mutation of prothrombin gene F2(20210)GA

Vestnik Dermatologii i Venerologii
The article describes a case of skin vasculopathy due to systemic coagulopathy. In the setting of complete well-being, a 37-year-old female patient developed extensive areas of skin necrosis, predominantly in the lower extremities, over a period of 3 ...
Anastasiia D. Kovaleva, Maria V. Sokolova, Aleksandr V. Patrushev, Irena E. Belousova   +3 more
doaj   +1 more source

Tests on the Accuracy of Basel II [PDF]

Basel II rules allow qualified banks to assess the risk in their portfolio of credit exposures with a methodology based on the informational content of credit ratings and two crucial assumptions: (1) the credit risk of individual exposures is driven by ...
Simone Varotto
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tia Factor (Art Forum)

, 2007
Tia Factor talks about a series of landscape paintings produced after a residency at the Port Arthur Historic ...
Factor, T
core   +1 more source

A novel tumour enhancer function of Insulin-like growth factor II mRNA-binding protein 3 in colorectal cancer. [PDF]

Cell Death Dis, 2023
Di Fusco D, Di Grazia A, Di Maggio G, Segreto MT, Iannucci A, Maresca C, De Stefano A, Sica G, Stolfi C, Monteleone G, Monteleone I.   +10 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Insulin-Like Growth Factor-II and Ischemic Stroke-A Prospective Observational Study. [PDF]

Life (Basel), 2021
Åberg D, Åberg ND, Jood K, Redfors P, Blomstrand C, Isgaard J, Jern C, Svensson J.   +7 more
europepmc   +1 more source

Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells

, 1996
We have investigated the autocrine regulation of insulin-like growth factor-II (IGF-II) signaling by the insulin-like growth factor-I receptor (IGF-IR) and the insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-IIR) in MCF-7 breast cancer ...
Leav, B A, Pearce, A, Lippman, M E, Zweibel, J A, Yang, Z, Rasmussen, A, Ellis, M J, Cullen, K J   +7 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The impact factor story: Part II

Indian Journal of Ophthalmology, 2016
Sundaram Natarajan
doaj   +1 more source