Results 221 to 230 of about 14,739,736 (367)

Population Modeling of Factor IX Activity Following Administration of Fidanacogene Elaparvovec Gene Therapy in Participants with Hemophilia B. [PDF]

Clin Pharmacokinet
Wojciechowski J, Gaitonde P, Hughes JH, Ravva P.   +3 more
europepmc   +1 more source

Differences in wild-type- and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies. [PDF]

Blood Adv, 2023
Foley JH, Shehu E, Riddell A, Gray E, Goodale A, Yu IM, Verhoef D, Little J, Shattock D, Kitchen S, Chowdary P, Corbau R, Nathwani AC.   +12 more
europepmc   +1 more source

Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain.

, 1992
S Paul Bajaj, AK Sabharwal, J Gorka, JJ Birktoft   +3 more
openalex   +2 more sources

Expression of active human blood clotting factor IX in transgenic mice: use of a cDNA with complete mRNA sequence [PDF]

, 1987
K.H. Andy Choo, K. Raphael, W. McAdam, M G Peterson   +3 more
openalex   +1 more source

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

Advanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira, Fábio M. de Azevedo, Ingrid G. S. Lins, Janaína C. O. Crispim, Giovanna A. Lira, Rômulo S. Cavalcante, Ricardo Cobucci, Carolina O. Mendes‐Aguiar, Rafaela Torres Dantas Da Silva, Vinícius E. da Silva, Ryan C. Q. Aquino, Raimundo F. Araújo Júnior   +11 more
wiley   +1 more source

Evaluation of One-Stage Assays for the Monitoring of Recombinant Human Factor IX Padua Activity After Etranacogene Dezaparvovec Gene Therapy. [PDF]

Haemophilia
Astermark J, Miesbach W, Coppens M, Gielen S, Twisk J, Dolmetsch R, Verweij S, Monahan PE, Ewenstein BM, Nuthalapati S, Galante N, Young G, HOPE‐B study investigators.   +12 more
europepmc   +1 more source

Stable and durable factor IX levels in patients with hemophilia B over 3 years after etranacogene dezaparvovec gene therapy. [PDF]

Blood Adv, 2023
von Drygalski A, Gomez E, Giermasz A, Castaman G, Key NS, Lattimore SU, Leebeek FWG, Miesbach WA, Recht M, Gut R, Dolmetsch R, Monahan PE, Le Quellec S, Pipe SW.   +13 more
europepmc   +1 more source

Japanese subject subpopulation analysis of B-LONG: a Phase 3 study of long-acting recombinant factor IX Fc fusion protein

, 2015
Midori Shima, Katsuyuki Fukutake, Hideji Hanabusa, Tadashi Matsushita, Masashi Taki, Michio Sakai, Toshiyuki Hirakata, Yingwen Dong, Shuanglian Li, Lynda M. Cristiano, Glenn F. Pierce, Baisong Mei   +11 more
openalex   +2 more sources

Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone

Advanced Biology, EarlyView.
In this study, Seaman et al. develop a co‐culture assay to examine interactions between prostate cancer cells and mineralized osteoblasts in a microfluidic platform. The authors collect conditioned media from static or flow‐stimulated osteocytes and demonstrate that mechanical loading of osteocytes regulates the growth of prostate cancer cells and ...
Kimberly Seaman, Bryan Guo, William W. Du, Burton Yang, Yu Sun, Lidan You   +5 more
wiley   +1 more source

Factor IX and deep vein thrombosis

Haematologica, 2009
Gordon Lowe
doaj   +1 more source