Results 71 to 80 of about 14,739,736 (367)
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2006 Se purificó a partir de la leche de cerdas transgénicas, factor IX recombinante, y se obtuvieron rendimientos entre 1 a 2 g de esta proteína por litro, lo que resulta una nueva vía para la obtención de este producto con una alta eficiencia, ya que su ...
Armando Cádiz Lahens +10 more
doaj
Signaling mechanisms of the platelet glycoprotein Ib-IX complex
Platelets, 2022 The glycoprotein Ib–IX (GPIb-IX) complex mediates initial platelet adhesion to von Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and transmits VWF binding-induced signals to stimulate platelet activation.
Yaping Zhang +3 more
doaj +1 more source
Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies
EMBO Molecular Medicine, 2013 Formation of pathogenic antibodies is a major problem in replacement therapies for inherited protein deficiencies. For example, antibodies to coagulation factors (‘inhibitors’) seriously complicate treatment of haemophilia.
D. Markusic +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Pemanfaatan Media Powerpoint dalam Pembelajaran Pkn Model Kooperatif untuk Perolehan Perilaku Belajar Siswa di Kelas IX [PDF]
, 2015 The success of students in learning activities, can not be separated from the behavior of students in the learning factor. Powerpoint media utilization and models of cooperative learning in class IX Civics Junior High School for the acquisition of ...
Gustamnur, G. (Gustamnur) +2 more
core +2 more sources
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Deuteron distribution in nuclei and the Levinger's factor [PDF]
, 2003 We compute the distribution of quasideuterons in doubly closed shell nuclei. The ground states of $^{16}$O and $^{40}$Ca are described in $ls$ coupling using a realistic hamiltonian including the Argonne $v_{8}^\prime$ and the Urbana IX models of two ...
A. Akmal +39 more
core +2 more sources
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source
Haematologica, 2020 Hemophilia B is an X-linked recessive bleeding disorder caused by abnormalities in the coagulation factor IX gene. Without prophylactic treatment, patients experience frequent spontaneous bleeding episodes.
Jiahuan Chen +14 more
doaj +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source