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Factor V Leiden: A Clinical Review
The American Journal of the Medical Sciences, 2001Factor V Leiden is the most prevalent genetic thrombophilia in people of European descent. Since its discovery, much clinical information has been gathered regarding the distribution and prevalence of the genetic mutation, the mechanism of thrombophilia, and its association with clinical thromboembolic events.
Norman M. Kaplan +2 more
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Homozygous factor V Leiden and double heterozygosity for factor V Leiden and prothrombin mutation
Journal of Thrombosis and Thrombolysis, 2012The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM). Homozygous FVL and PTM have long been feared conditions thought to cause high rates of morbidity and mortality. To analyse clinical features in patients with homozygous FVL and PTM, as well as patients with double heterozygosity for FVL and PTM ...
Ymir, Saemundsson +3 more
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Factor V Leiden: a disorder of factor V anticoagulant function
Current Opinion in Hematology, 2004Activated protein C (APC) resistance, which is often associated with the factor V R506Q (FV Leiden) mutation, is a common risk factor for venous thrombosis. Study of the mechanism of APC resistance has revealed that coagulation FV stimulates the APC-catalysed inactivation of FVIIIa, and that this anticoagulant function of FV is impaired in FV Leiden ...
Elisabetta, Castoldi, Jan, Rosing
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Factor V Leiden Mutation in Pregnancy
Journal of Obstetric, Gynecologic & Neonatal Nursing, 2004Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations ...
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Factor V Leiden and Perioperative Risk
Anesthesia & Analgesia, 2004Factor V Leiden (FVL) is the most common known inherited cause of thrombophilia; it is present in approximately 5% of the Caucasian population. Although the risk of venous thrombosis associated with this polymorphism in various medical settings is well described, its effect on perioperative risk is only beginning to be explored. Specifically, there are
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Clinical characteristics: Factor V Leiden thrombophilia is characterized by venous thromboembolism (VTE) manifesting most commonly in adults as deep vein thrombosis (DVT) in the legs or pulmonary embolism. Thrombosis in unusual locations is less common.
Pastori, Daniele +3 more
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Pastori, Daniele +3 more
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Factor V Leiden paradox in Factor V Leiden homozygotes – a retrospective cohort study
Hämostaseologie, 2023B Luxembourg, W Miesbach, H Gall
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