Results 51 to 60 of about 13,721,448 (320)

The frequency of factor V Leiden and concomitance of factor V Leiden

, 2007
Factor V Leiden causing activated protein C resistance is the most common inherited form of thrombophilia leading to thrombosis. Its frequency shows great ethnic and geographic variations. The aim of this study was to determine the frequency of FV Leiden and coinheritance of FV Leiden with two other frequent hereditary thrombophilia causes, namely ...
Kabukcu, S, Keskin, N, Keskin, A, Atalay, E   +3 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

archeologisch bureauonderzoek naar de Nobellocatie aan de Marktsteeg en Lange Scheistraat te Leiden

, 2010
In opdracht van het Projectmanagementbureau van de gemeente Leiden heeft de Unit Monumenten & Archeologie van de gemeente Leiden een archeologisch bureauonderzoek uitgevoerd naar de Nobellocatie te Leiden.
Brandenburgh, C.R.
core   +1 more source

Triangular Index Ratio as an Alternative Method to the Alpha Angle for Defining the Presence of Cam Morphology: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective Cam morphology, which is a significant risk factor for hip osteoarthritis, is commonly quantified by the alpha angle (AA). This study aims to explore the potential of the triangular index ratio (TIR) to quantify cam morphology on anteroposterior radiographs by assessing the association between TIR‐defined cam morphology and the development of
Jinchi Tang, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Myrthe A. van den Berg, Jos Runhaar, Sita Bierma‐Zeinstra, Rintje Agricola   +7 more
wiley   +1 more source

Attenuation of phenotypical expression of severe hemophilia A in presence of simultaneous prothrombotic Factor V mutation: The debate continues

Journal of Family Medicine and Primary Care, 2019
The effect of coexistence of the prothrombotic Factor V Leiden mutation on the phenotypical expression in hemophilia is still debatable. Six-year-old boy with severe hemophilia A had presented with large soft tissue hematoma, treated with Factor VIII ...
Saugata Acharyya, Kakoli Acharyya, Archana Parasar, Shanto Pramanik   +3 more
doaj   +1 more source

Comparative frequency of Coagulation Factor II and Coagulation Factor V Alleles among new-born and senior citizens [PDF]

, 2005
Resistance to activated protein C is one of the most common inherited disorders associated with hereditary thrombophilia. A missense mutation in the gene coding for coagulation factor V (CF V Leiden) and which renders this procoagulant factor resistant ...
Bezzina Wettinger, Stephanie, Scerri, Christian A., Felice, Alex, Abela Medici, Joseph, Grochowska, Alicha   +4 more
core  

Biopsychosocial Determinants of Hand Function and Its Trajectories Over Five Years in Patients With Hand Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate hand function trajectories over five years in primary hand osteoarthritis (OA). Additionally, determinants of baseline and longitudinal hand function were assessed. Methods A total of 538 patients with both baseline and five‐year study visits were analyzed.
Annemiek V. E. M. Olde Meule, Coen van der Meulen, Jos Runhaar, Frits R. Rosendaal, Margreet Kloppenburg   +4 more
wiley   +1 more source

Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population

Genetics and Molecular Biology, 2009
Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q).
Magaly B.P.L.V. Lima, Aldemir Branco de Oliveira-Filho, Júlia F. Campos, Fárida C.B.C. Melo, Washington Batista das Neves, Raul Antônio Morais Melo, José Alexandre Rodrigues Lemos   +6 more
doaj   +1 more source

Factor V Leiden and the Risk of Bleeding in Patients With Acute Coronary Syndromes Treated With Antiplatelet Therapy: Pooled Analysis of 3 Randomized Clinical Trials

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Whether factor V Leiden is associated with lower bleeding risk in patients with acute coronary syndromes using (dual) antiplatelet therapy has yet to be investigated.
Bakhtawar K. Mahmoodi, Niclas Eriksson, Stephanie Ross, Daniel M. F. Claassens, Folkert W. Asselbergs, Karina Meijer, Agneta Siegbahn, Stefan James, Guillaume Pare, Lars Wallentin, Jurriën M. ten Berg   +10 more
doaj   +1 more source

Een archeologisch bureauonderzoek naar het tracé van de Ringweg Oost in Leiden en Leiderdorp

, 2010
In opdracht van het Projectmanagementbureau van de gemeente Leiden heeft de Unit Monumenten & Archeologie van de gemeente Leiden een archeologisch bureauonderzoek uitgevoerd naar het tracé van de Ringweg Oost in Leiden en Leiderdorp.
Brandenburgh, C.R.
core   +1 more source