Results 51 to 60 of about 14,445,357 (297)

Rastreamento familiar do fator V de Leiden: a importância da detecção de portadores heterozigotos Familiar tracking of factor V Leiden: the importance of detection in heterozygous carriers

Revista Brasileira de Hematologia e Hemoterapia, 2005
O fator de Leiden é uma mutação genética que predispõe seus portadores ao tromboembolismo venoso. O objetivo do estudo foi investigar a distribuição dos alelos em 21 membros da família de três pacientes portadores de trombose com a presença da mutação do
Eunice B. Carvalho, Maria I.M.C. Pardini, Rosângela A.R.R. Holanda, Gentil C. Galiza-Neto, Sílvia M.M. Magalhães, Maria H.S. Pitombeira, Milena V. Holanda, Ailton T. Fontenele-Filho, Silvia H. B. Rabenhorst   +8 more
doaj   +1 more source

Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns

Arthritis Care &Research, Accepted Article.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen, Yasuo Nagafuchi, Kristina Lend, Seyam Alemyar, Herman Kasper Glas, Gerdur Gröndal, Bjorn Gudbjornsson, Espen A. Haavardsholm, Kim Hørslev Petersen, Jon Lampa, Merete Lund Hetland, Dan Nordström, Mike Nurmohamed, Mikkel Østergaard, Anna Rudin, Marte Schrumpf Heiberg, Tuulikki Sokka‐Isler, Till Uhlig, Josien Veris‐van Dieren, Ronald van Vollenhoven, Tom Huizinga, Marcel JT Reinders, Sytske Anne Bergstra, Erik van den Akker, Rachel Knevel   +24 more
wiley   +1 more source

FACTOR V LEIDEN MUTATIONS AND UNILATERAL RETINAL VEIN OCCLISION: A REGIONAL STUDY OF EASTERN PART OF TURKEY

Eurasian Journal of Medicine, 2019
Purpose: We investigated the role of factor V Leiden mutation in patients with retinal vein occlusion (RVO). Method: Factor V Leiden mutation was investigated in DNA obtained from the peripheral blood of 30 patients, diagnosed with retinal vein ...
Orhan Ateş, Orhan Baykal
doaj  

Estimating the Prevalence and Incidence of Symptomatic Hand Osteoarthritis in the Netherlands Using Primary Care Electronic Health Records

Arthritis Care &Research, EarlyView.
Objective Estimating the incidence and prevalence of symptomatic hand osteoarthritis (OA) in the Dutch population using a validated algorithm that integrates free‐text data from primary care electronic health records (EHRs). Methods This retrospective cohort study used the Integrated Primary Care Information database, including EHRs from approximately ...
Onur Kaya, Jacoline van den Driest, Laura Struik, Margreet Kloppenburg, Ruud Selles, Daniel Prieto Alhambra, Sita Bierma‐Zeinstra, Dieuwke Schiphof   +7 more
wiley   +1 more source

The Association between Preeclampsia and Defined Polymorphisms in Prothrombin and Coagulation Factor V Genes [PDF]

Journal of Kerman University of Medical Sciences, 2016
Background & Aims: Preeclampsia is one of the complications of pregnancy and a major cause of maternal mortality. Since, hypercoagulation is one of the risk factors, defined polymorphisms of V and II coagulation factors (G1691A and G20210A) may increase ...
Zohreh Salari, Nasrollah Saleh-gohari, Nushin Zainali, Neda Salmani-Cheharfarsakhi   +3 more
doaj  

Factor V Leiden Mutation and Pregnancy [PDF]

The Journal of the American Board of Family Medicine, 2004
Factor V Leiden mutation (FVL) is an autosomal dominant hemostatic disorder that predisposes affected persons to venous thromboembolic events (VTE). Although the mutation causing FVL is easily diagnosed using molecular DNA techniques,[1][1] patients who are heterozygous for this disorder ...
openaire   +2 more sources

Factor‐V Leiden: a risk factor for cerebral palsy [PDF]

Developmental Medicine & Child Neurology, 1999
Inherited and acquired thrombophilic disorders have recently been associated with cerebral palsy (CP) and complications in pregnancy. Thrombophilic disorders are not diseases per se, but are recognized risk factors for a variety of diseases across all ages, including atherosclerosis, cerebral infarction, inflammatory bowel disease, Legg–Perthes disease,
K H, Harum, A H, Hoon, J F, Casella
openaire   +2 more sources

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Prevention of thromboembolic events after radical prostatectomy in patients with hereditary thrombophilia due to a factor V Leiden mutation by multidisciplinary coagulation management

Asian Journal of Urology
Objective: To examine the perioperative impact of factor V Leiden mutation on thromboembolic events' risk in radical prostatectomy (RP) patients. With an incidence of about 5%, factor V Leiden mutation is the most common hereditary hypercoagulability ...
Randi M. Pose, Sophie Knipper, Jonas Ekrutt, Mara Kölker, Pierre Tennstedt, Hans Heinzer, Derya Tilki, Florian Langer, Markus Graefen   +8 more
doaj   +1 more source