Results 21 to 30 of about 77,059 (283)

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance

Hepatology Communications, EarlyView., 2022
Abstract Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed.
Martijn P. D. Haring, Arthur K. E. Elfrink, Christiaan A. J. Oudmaijer, Paul C. M. Andel, Alicia Furumaya, Nenke de Jong, Colin J. J. M. Willems, Thijs Huits, Julie M. L. Sijmons, Eric J. T. Belt, Koop Bosscha, Esther C. J. Consten, Mariëlle M. E. Coolsen, Peter van Duijvendijk, Joris I. Erdmann, Paul Gobardhan, Robbert J. de Haas, Tjarda van Heek, Hwai‐Ding Lam, Wouter K. G. Leclercq, Mike S. L. Liem, Hendrik A. Marsman, Gijs A. Patijn, Türkan Terkivatan, Babs M. Zonderhuis, Izaak Quintus Molenaar, Wouter W. te Riele, Jeroen Hagendoorn, Alexander F. M. Schaapherder, Jan N. M. IJzermans, Carlijn I. Buis, Joost M. Klaase, Koert P. de Jong, Vincent E. de Meijer, the Dutch Benign Liver Tumor Group, R. B. Takkenberg, J. Verheij, O. M. van Delden, J. I. Erdmann, B. V. van Rosmalen, A. Furumaya, G. Kazemier, D. Ramsoekh, J. N. M. IJzermans, R. A. de Man, M. D. Doukas, M. G. Thomeer, A. J. Klompenhouwer, A. F. M. Schaapherder, M. E. Tushuizen, M. J. Coenraad, A. S. L. P. Crobach, M. C. Burgmans, S. Feshtali, M. M. E. Coolsen, M. Kramer, J. C. Beckervordersandforth, I. V. Samarska, C. van der Leij, R. Miclea, J. H. W. de Wilt, P. B. van den Boezem, E. T. T. L. Tjwa, I. Munsterman, S. Vos, S. van Koeverden, V. E. de Meijer, F. J. C. Cuperus, R. J. de Haas, E. W. Duiker, M. P. D. Haring   +70 more
wiley   +1 more source

Inherited and acquired risk factors and their combined effects in pediatric stroke [PDF]

, 2003
The aim of this study was to identify hereditary and acquired risk-factors as they are related to the occurrence of stroke in children. We identified 21 children with stroke.
Barbot, Clara, Barbot, José, Barreirinho, Maria Sameiro, Costa, Elísio, Ferro, Anabela, Maciel, Patricia, Pinto-Bastos, Jorge, Santos, Manuela, Sequeiros, Jorge, Sousa, Alda   +9 more
core   +1 more source

Factor V Leiden Mutation and Pregnancy [PDF]

The Journal of the American Board of Family Medicine, 2004
Factor V Leiden mutation (FVL) is an autosomal dominant hemostatic disorder that predisposes affected persons to venous thromboembolic events (VTE). Although the mutation causing FVL is easily diagnosed using molecular DNA techniques,[1][1] patients who are heterozygous for this disorder ...
openaire   +2 more sources

Factor V Leiden and venous thrombosis: First case report from Iraq

مجلة كلية الطب, 2005
Background: Factor V Leiden mutation is the most common cause of hereditary thrombophilia . this mutation was found to be highly prevalent in the Eastern Mediterranean region , with recently reported prevalence of 3% in random Iraqi blood donors.
Nasir AL-Allawi, Ferial Hilmi, Jaladet M.S. Jubrael, Ali M. Al-Ameri   +3 more
doaj   +1 more source

Analysis of polymorphisms Leiden Factor V G1691A and prothrombin G20210A as risk factors for acute myocardial infarction. [PDF]

, 2011
Thrombotic risk increases in elderly, therefore, the understanding of the genetic predisposition of hypercoagulability could make the difference in the prevention of venous and/or arterial thrombotic events.
Branzi, A, Caldarera, CM, CARUSO, Calogero, FORTE, Giusi Irma, Licastro, F, LIO, Domenico, PALMERI, Marisa, SCOLA, Letizia, VACCARINO, Loredana   +8 more
core   +1 more source

Factor V Leiden Mutation - an Unusual Cause of Hypopituitarism?

Endocrinology Research and Practice, 2022
Hypopituitarism is a disorder of diverse etiology that results in partial or total loss of pituitary functions. Here we report a 49-year-old female patient presenting with absence of peripheral pulses of the right upper extremity and anterior pituitary ...
Ekrem Algün, Ergin Sencer, Yusuf Orhan, Ferihan Aral, Adil Azezli, Neşe Özbey, Ali Said Turgut, Filiz Sürücü, Leyla Yılmaz Gürbüz, Senay Molvalılar   +9 more
doaj   +2 more sources

Attenuation of phenotypical expression of severe hemophilia A in presence of simultaneous prothrombotic Factor V mutation: The debate continues

Journal of Family Medicine and Primary Care, 2019
The effect of coexistence of the prothrombotic Factor V Leiden mutation on the phenotypical expression in hemophilia is still debatable. Six-year-old boy with severe hemophilia A had presented with large soft tissue hematoma, treated with Factor VIII ...
Saugata Acharyya, Kakoli Acharyya, Archana Parasar, Shanto Pramanik   +3 more
doaj   +1 more source

The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease [PDF]

, 2006
Sickle cell disease (SCD) is one of the most common inherited diseases in the world and the patients present notorious clinical heterogeneity. It is known that patients with SCD present activation of the blood coagulation and fibrinolytic systems ...
Beltrão, A.c.s., Figueiredo, Maria Stella, Gil, I.c.p., Lourenco, Dayse Maria, Moreira Neto, F., Morelli, V.m., Noguti, Maria Aparecida Eiko   +6 more
core   +3 more sources